Influence of Sarcopenia on Ventricular Remodeling Post-CABG in Aged Individuals

Overview

This study investigates the impact of sarcopenia on ventricular remodeling following coronary artery bypass grafting (CABG) in elderly patients with coronary heart disease (CHD). It identifies sarcopenia as a significant independent risk factor for ventricular remodeling, with a notable predictive efficacy.

Background

The prevalence of coronary heart disease (CHD) is increasing among the elderly, necessitating effective interventions like CABG. Sarcopenia, characterized by muscle loss and functional decline, is common in this population and may adversely affect postoperative outcomes. Understanding the relationship between sarcopenia and ventricular remodeling is crucial for improving patient management and outcomes after CABG.

Data Highlights

Key Findings

• The incidence of ventricular remodeling after CABG was 23.70% in the study cohort.
• Sarcopenia was identified as an independent risk factor for ventricular remodeling (OR = 2.230).
• Other significant risk factors included smoking history, diabetes, and elevated levels of Lp(a), UA, PAR2, and MHR.
• Sarcopenia demonstrated a sensitivity of 90.0% and specificity of 47.0% for predicting ventricular remodeling.
• Multivariable logistic regression analysis highlighted several clinical parameters associated with increased risk of ventricular remodeling.

Clinical Implications

Clinicians should consider assessing sarcopenia in elderly patients undergoing CABG, as it is a significant predictor of adverse remodeling outcomes. Early identification of sarcopenia may facilitate targeted interventions to improve postoperative prognosis.

Conclusion

Sarcopenia significantly influences ventricular remodeling after CABG in elderly patients with CHD, highlighting the need for integrated assessments of muscle health in this population.

References

1. European Journal of Preventive Cardiology, 2023 -- Sarcopenia in heart failure: insights from the global leadership initiative on sarcopenia framework
2. Clinical Research in Cardiology, 2024 -- Physiological Cardiac Remodeling Patterns Related to Age and Sex: Investigating the Quest for Longevity
3. Clinical Research in Cardiology, 2023 -- The Relationship Between Sarcopenia, Its Components, and All-Cause Mortality in Heart Failure: A Systematic Review and Meta-Analysis
4. Hernia, 2020 -- The Growing Significance of Sarcopenia as a Prognostic Factor in Patients Undergoing Abdominal Wall Hernia Surgery: A Comprehensive Literature Review
5. Nature Aging, 2025 -- A focus shift from sarcopenia to muscle health in the Asian Working Group for Sarcopenia 2025 Consensus Update
6. Frontiers in Public Health, 2024 -- Ct-based diagnosis of sarcopenia as a prognostic factor for postoperative mortality after elective open-heart surgery in older patients: a cohort-based systematic review and meta-analysis
7. American College of Cardiology, 2016 -- Undergoing CABG for Ischemic Cardiomyopathy Improves 10-Year Mortality Risk
8. A focus shift from sarcopenia to muscle health in the Asian Working Group for Sarcopenia 2025 Consensus Update | Nature Aging
9. Ct-based diagnosis of sarcopenia as a prognostic factor for postoperative mortality after elective open-heart surgery in older patients: a cohort-based systematic review and meta-analysis
10. Undergoing CABG for Ischemic Cardiomyopathy Improves 10-Year Mortality Risk - American College of Cardiology