Profiles of Clinical, Metabolomic, and Proteomic Factors Linked to Reproductive Outcomes in Cases of Unexplained Recurrent Pregnancy Loss
Overview
This study identifies clinical and multi-omics factors associated with conception and early pregnancy loss in women with unexplained recurrent pregnancy loss (URPL). Key findings include associations between hormonal levels and reproductive outcomes.
Background
Recurrent pregnancy loss (RPL) affects 2-5% of couples globally and poses significant emotional and physical challenges. Despite thorough evaluations, many cases remain unexplained, classified as unexplained recurrent pregnancy loss (URPL). Understanding the factors influencing URPL is crucial for improving clinical management and patient outcomes.
Data Highlights
Outcome
Result
Conception Rate
66.4% (99/149)
Ongoing Pregnancy Rate
67.7% (67/99)
Early Pregnancy Loss Rate
32.3% (32/99)
Adjusted Odds Ratio for Higher Testosterone
0.50 (95% CI 0.28–0.89, p = 0.019)
Higher Prolactin and Early Pregnancy Loss
aOR 1.09 (95% CI 1.01–1.18, p = 0.036)
Lower Odds of Early Pregnancy Loss with Higher 7α,12α-dihydroxy-3-oxocholest-4-en-27-oic Acid
aOR 0.64 (95% CI 0.44–0.95, p = 0.025)
Key Findings
66.4% of women with URPL conceived during the follow-up period.
Higher testosterone levels were associated with lower odds of conception (aOR 0.50).
Women who conceived had higher levels of progesterone-related metabolites.
Higher prolactin levels were linked to increased odds of early pregnancy loss (aOR 1.09).
Early pregnancy loss was characterized by lower bile acid-related metabolites.
7α,12α-dihydroxy-3-oxocholest-4-en-27-oic acid was associated with lower odds of early pregnancy loss (aOR 0.64).
Clinical Implications
The findings indicate associations between hormonal and metabolic profiles and reproductive outcomes for women with URPL.
Conclusion
This study highlights the associations of hormonal and metabolic factors in unexplained recurrent pregnancy loss.
