Clinical Report: Rare Electrolyte Abnormalities in Primary Hyperparathyroidism
Overview
This case study presents a 74-year-old woman with primary hyperparathyroidism (PHPT) exhibiting rare electrolyte abnormalities, including severe hypomagnesemia and hypokalemia.
Background
Primary hyperparathyroidism (PHPT) is typically characterized by hypercalcemia, hypophosphatemia, and hypercalciuria. The occurrence of hypokalemia and hypomagnesemia is rare in PHPT.
Data Highlights
Parameter
Value
Serum Calcium
4.18 mmol/L
Intact PTH
243.0 pg/mL
Serum Magnesium
0.23 mmol/L
Serum Potassium
2.5 mmol/L
Vitamin D Level
14.2 ng/mL
Calcium-to-Creatinine Clearance Ratio
0.0093
Key Findings
The patient presented with metabolic encephalopathy and dehydration due to severe hypercalcemia.
Biochemical analysis revealed hypokalemia, hypomagnesemia, and hypophosphatemia.
Urine analysis indicated renal potassium and magnesium wasting with severe hypocalciuria.
Vitamin D deficiency was noted.
Postoperative hypercalcemia resolved, but hypomagnesemia persisted.
Clinical Implications
Clinicians should consider the possibility of renal tubulopathies in patients with PHPT who present with hypokalemia and hypomagnesemia.
Conclusion
This case highlights the presence of atypical electrolyte disturbances in PHPT.
