Correction: Channel selection of metagenomic next-generation sequencing in infants pathogen detection: a multicenter cross-sectional study - Report - MDSpire
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Correction: Channel selection of metagenomic next-generation sequencing in infants pathogen detection: a multicenter cross-sectional study
Clinical Report: Correction on Channel Selection in mNGS for Pathogen Detection
Overview
This report corrects previous errors in a multicenter study on metagenomic next-generation sequencing (mNGS) for pathogen detection in infants. Key corrections include updated positivity rates and author affiliations, which are critical for accurate interpretation of the study's findings.
Background
Metagenomic next-generation sequencing (mNGS) is increasingly utilized for pathogen detection in pediatric populations, particularly in infants where conventional microbiologic tests may be insufficient. Accurate channel selection (DNA-only, RNA-only, or combined) is essential for optimizing diagnostic outcomes. This correction highlights the importance of precise data reporting and author affiliations in clinical research.
Data Highlights
Key corrections include: Sputum samples showed a 53.7% positivity rate (87/162), increasing to 82.35% (14/17) with dual-channel detection. The overall positive rate for samples sent for testing was 51.90% (464/894).
Key Findings
Correction of author affiliation for Yang Shumei to the appropriate institution.
Updated positivity rates for sputum samples using dual-channel detection.
Overall positive rate for samples sent for testing corrected to 51.90%.
Significant differences in positivity rates between combined-sequencing modalities and single-channel methods.
Funding sources for the study have been clarified.
Clinical Implications
Clinicians should be aware of the importance of accurate data reporting in mNGS studies to ensure proper interpretation and application of findings. The choice of sequencing channels can significantly impact diagnostic accuracy, underscoring the need for careful specimen selection and assay validation.
Conclusion
This correction emphasizes the critical nature of accurate data in clinical research and the implications for pathogen detection strategies in infants. Continued refinement of mNGS methodologies will enhance diagnostic capabilities in pediatric infectious diseases.
