Daily-life dynamics of general and cognitive fatigue in childhood cancer survivors: An experience sampling and wearable study - Report - MDSpire
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Daily patterns of general and cognitive fatigue among childhood cancer survivors: An experience-sampling and wearable-device study

  • By

  • Deveny Vanrusselt

  • Charlotte Sleurs

  • Nicolas Leenaerts

  • Stefan Kirsch

  • Nel Van Ermengem

  • Jurgen Lemiere

  • Inez Myin-Germeys

  • Anne Uyttebroeck

  • Sabine Verschueren

  • October 12, 2026

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Clinical Report: Daily Patterns of Fatigue in Childhood Cancer Survivors

Overview

The article frames general and cognitive fatigue as distinct experiences that may vary within childhood cancer survivors (CCS) during daily life. It identifies momentary tension, sleep, recent physical activity, and symptom inertia as potential influences, while emphasizing that their short-term, within-person relationships remain insufficiently understood in the supplied text.

Background

Fatigue can persist for years after childhood cancer treatment and is associated with impaired quality of life, everyday functioning, and psychosocial well-being. General fatigue describes overall tiredness and reduced energy, whereas cognitive fatigue concerns difficulty sustaining mental effort, concentration, and cognitive functioning. Prior CCS research has more often examined general or overall fatigue, although the source reports that the two dimensions have partly distinct correlates. The supplied introduction identifies a need to characterize how each dimension changes over short periods in everyday life.

Data Highlights

The supplied article text contains no study sample size, numerical results, or trial estimates. It describes the study as using experience sampling and wearable devices but does not provide methods or findings beyond the introduction.

Key Findings

  • The article distinguishes general fatigue from cognitive fatigue and notes that prior work in CCS has linked these dimensions to partly different correlates.
  • In the authors’ prior work, cognitive fatigue was especially associated with cognitive and school/work functioning; general fatigue and sleep/rest fatigue had broader relationships with psychosocial functioning.
  • The introduction reports that poorer sleep quality was associated with greater general fatigue, while its relationship with cognitive fatigue varied by cardiorespiratory fitness.
  • Momentary tension is presented as a possible predictor of later fatigue, but the supplied text states that this temporal relationship remains uncertain.
  • Prior sleep findings in CCS have mainly concerned retrospective general fatigue and between-person differences, leaving short-term within-person fluctuations less understood.
  • Related guidance supports regular fatigue surveillance in childhood, adolescent, and young adult cancer survivors; the International Late Effects of Childhood Cancer Guideline Harmonization Group recommends regular screening with validated measures.

Clinical Implications

The supplied context supports distinguishing general from cognitive fatigue when assessing survivors, rather than assuming that the same factors influence both. It also describes guideline recommendations for regular fatigue screening using validated measures; the provided article excerpt does not report results that establish specific moment-to-moment triggers or interventions.

Conclusion

The supplied introduction presents daily variation in general and cognitive fatigue as an important but incompletely characterized aspect of survivorship. The study’s results are not included in the provided material, so its empirical findings cannot be summarized here.

Related Resources & Content

  1. Mulrooney DA, Mertens AC, Neglia JP, et al., Journal of Clinical Oncology, 2004 — Fatigue and sleep in survivors of childhood cancer: A report from the Childhood Cancer Survivor Study (CCSS)
  2. International Late Effects of Childhood Cancer Guideline Harmonization Group, 2020 — Recommendations for the surveillance of cancer-related fatigue in childhood, adolescent, and young adult cancer survivors
  3. Children’s Oncology Group, 2025 — The Children’s Oncology Group Long-Term Follow-Up Guidelines for Survivors of Childhood, Adolescent, and Young Adult Cancers
  4. ASCO Publications — Fatigue and health behaviors in cancer survivors: A cross-sectional population based study.
  5. ASCO Publications — Self-reported sleep difficulties and association with cognitive function in pediatric cancer survivors.
  6. ASCO Publications — Self-reported sleep difficulties and association with cognitive function in pediatric cancer survivors.
  7. Recommendations for the surveillance of cancer-related fatigue in childhood, adolescent, and young adult cancer survivors
  8. The Children’s Oncology Group Long-Term Follow-Up Guidelines for Survivors of Childhood, Adolescent, and Young Adult Cancers
  9. The Children’s Oncology Group Long-Term Follow-Up Guidelines for Survivors of Childhood, Adolescent, and Young Adult Cancers - PMC
  10. Recommendations for the surveillance of cancer-related fatigue in childhood, adolescent, and young adult cancer survivors: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group - PMC
  11. Date
  12. Grading the evidence on the effects of exercise interventions in children and adolescents during and beyond cancer treatment: an umbrella review of systematic reviews with meta-analyses
  13. Fatigue Scale for Children With Cancer: A Systematic Review and Reliability Generalization Meta-analysis - PubMed
  14. A pilot study of device-assessed physical activity and ecological momentary assessment among adolescent and young adult survivors of childhood cancer - PubMed

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