Integrated left ventricular geometry–function phenotypes and long-term outcomes after acute myocardial infarction - Report - MDSpire

Integrated left ventricular geometry–function phenotypes and long-term outcomes after acute myocardial infarction

  • By

  • Seonmin Park

  • Seok Oh

  • Yongwhan Lim

  • Joon Ho Ahn

  • Dae Young Hyun

  • Seung Hun Lee

  • Kyung Hoon Cho

  • Min Chul Kim

  • Doo Sun Sim

  • Ju Han Kim

  • Youngkeun Ahn

  • Myung Ho Jeong

  • Jong Pil Park

  • Jay Young Rhew

  • Young Joon Hong

  • June 22, 2026

  • 0 min

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Clinical Report: Combined Left Ventricular Geometry and Function Profiles

Overview

This study investigates the combined prognostic impact of left ventricular (LV) geometry and systolic function in patients following acute myocardial infarction (AMI). Findings indicate that LV dilatation's prognostic significance is contingent upon the presence of reduced ejection fraction.

Background

Left ventricular remodeling after AMI is a critical factor influencing long-term outcomes, yet the interaction between LV geometry and systolic function remains poorly understood. This study aims to clarify how different LV geometry-function phenotypes affect prognosis in a large cohort of AMI patients.

Data Highlights

GroupMACCE IncidenceHazard Ratio (HR)
A (non-dilated/preserved)13.2%-
B (dilated/preserved)13.5%1.13 (0.99–1.29)
C (non-dilated/reduced)16.8%1.12 (1.01–1.24)
D (dilated/reduced)21.9%1.44 (1.29–1.60)

Key Findings

  • The incidence of major adverse cardiac and cerebrovascular events (MACCE) increased from 13.2% in group A to 21.9% in group D.
  • LV dilatation alone did not increase risk in patients with preserved LVEF (group B vs. group A: HR 1.13).
  • LV dilatation was associated with higher risk when accompanied by reduced LVEF (group C: HR 1.12; group D: HR 1.44).
  • Real-world data on LV remodeling's impact on long-term outcomes post-AMI is limited, making this study significant.

Clinical Implications

The findings suggest that clinicians should consider both LV geometry and systolic function when assessing prognosis in AMI patients. This integrated approach may improve risk stratification and inform management decisions in clinical practice.

Conclusion

The study emphasizes the importance of evaluating both LV geometry and function to understand the prognosis of patients following AMI.

Related Resources & Content

  1. Frontiers in Medicine, 2026 -- Association of left ventricular geometry with outcomes and treatment response in atrial fibrillation and heart failure with preserved ejection fraction
  2. European Radiology, 2023 -- Contrast-Enhanced Cardiac MRI Outperforms Non-Contrast Mapping in Predicting Left Ventricular Remodeling Six Months Post-Acute Myocardial Infarction
  3. Clinical Research in Cardiology, 2021 -- Enhancing Risk Evaluation Post-ST-Segment Elevation Myocardial Infarction Through Global Longitudinal Strain: A Comparative Analysis of Left Ventricular Functional Metrics
  4. ACC, AHA Issue New Acute Coronary Syndromes Guideline - American College of Cardiology, 2025
  5. Empagliflozin after Acute Myocardial Infarction | New England Journal of Medicine, 2024
  6. European Radiology — Prognostic Significance of Left Atrial Strain in Apical Hypertrophic Cardiomyopathy: Insights from Cardiovascular Magnetic Resonance Imaging
  7. ACC, AHA Issue New Acute Coronary Syndromes Guideline - American College of Cardiology
  8. Empagliflozin after Acute Myocardial Infarction | New England Journal of Medicine
  9. Prognostic impact of left ventricular strain by feature tracking in acute myocardial infarction treated with PCI: A meta-analysis - ScienceDirect

Original Source(s)

Integrated left ventricular geometry–function phenotypes and long-term outcomes after acute myocardial infarction

  • by Seonmin Park, Seok Oh, Yongwhan Lim, Joon Ho Ahn, Dae Young Hyun, Seung Hun Lee, Kyung Hoon Cho, Min Chul Kim, Doo Sun Sim, Ju Han Kim, Youngkeun Ahn, Myung Ho Jeong, Jong Pil Park, Jay Young Rhew, Young Joon Hong

  • June 22, 2026

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