Neurological recovery after liver transplantation in a severely disabled adolescent with Wilson disease: a 1-year follow-up case report - Report - MDSpire
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Neurological recovery after liver transplantation in a severely disabled adolescent with Wilson disease: a 1-year follow-up case report
Neurological Improvement Following Liver Transplantation in Wilson Disease
Overview
This case study reports significant neurological recovery in a 15-year-old with advanced Wilson disease following liver transplantation. The patient demonstrated marked improvement in neurological function and quality of life one year post-surgery.
Background
Wilson disease is a genetic disorder characterized by copper accumulation, leading to severe hepatic and neurological complications. The management of patients with advanced neurological impairment due to Wilson disease poses significant challenges, particularly regarding the appropriateness of liver transplantation. Understanding the potential for recovery following transplantation is crucial for clinical decision-making.
Data Highlights
The patient's total UWDRS score improved from 162 at presentation to 59 at one year post-transplantation.
Key Findings
A 15-year-old female with severe neurological Wilson disease underwent liver transplantation.
Preoperative UWDRS score was 162, indicating profound neurological dysfunction.
Post-transplant, the patient regained speech, cognitive engagement, and the ability to walk with support.
Marked recovery was noted in daily activities, allowing the patient to return to school.
This case suggests that severe neurological impairment may not be an absolute contraindication for liver transplantation.
Clinical Implications
This case highlights the importance of considering liver transplantation in adolescents with severe neurological Wilson disease, as significant recovery is possible. Continuous neuropsychosocial rehabilitation post-transplant is essential for optimizing outcomes.
Conclusion
The findings from this case contribute to the growing evidence that liver transplantation can lead to substantial neurological improvement in patients with advanced Wilson disease.
