Atherogenic index of plasma predicts progression of diabetic kidney disease

By
Hong-Mou Shih
Sung-Chen Liu
Kuo-Liong Chien
Hsien-Yu Fan
Ming-Chieh Tsai
Shih-Ming Chuang
June 5, 2026
0 min

Frontiers In Medicine

Overview

This study investigates the association between the atherogenic index of plasma (AIP) and the progression of diabetic kidney disease (DKD) in adults with type 2 diabetes (T2D). Higher AIP levels were found to be independently linked to increased risks of albuminuria progression and sustained decline in estimated glomerular filtration rate (eGFR).

Background

Remove unsupported conclusions about the importance of identifying risk factors.

Data Highlights

Outcome	Adjusted HR (95% CI)	P-value
Albuminuria progression	1.25 (1.06–1.47)	0.007
Sustained eGFR decline	1.59 (1.25–2.02)	<0.001
Highest AIP quartile vs. lowest (albuminuria)	2.09 (1.23–3.57)	0.007
Highest AIP quartile vs. lowest (eGFR)	3.32 (1.53–7.24)	0.002

Key Findings

Higher AIP is independently associated with increased hazards of kidney outcomes in T2D.
Each standard deviation increase in AIP correlates with a 25% increased risk of albuminuria progression.
AIP is linked to a 59% increased risk of sustained eGFR decline per standard deviation increase.
Individuals in the highest AIP quartile have more than double the risk of albuminuria progression compared to those in the lowest quartile.
The highest quartile of AIP is associated with more than three times the risk of eGFR decline compared to the lowest quartile.

Clinical Implications

Monitoring AIP levels may provide valuable insights into the risk of DKD progression in patients with T2D. Clinicians should consider incorporating AIP assessment into routine evaluations to identify patients at higher risk for adverse kidney outcomes.

Conclusion

The atherogenic index of plasma may serve as a useful marker for predicting the risk of diabetic kidney disease progression in individuals with type 2 diabetes.