Retrobulbar spot sign in non-ischemic conditions: a case series challenging its diagnostic role - Report - MDSpire

Retrobulbar spot sign in non-ischemic conditions: a case series challenging its diagnostic role

  • By

  • Chuanjie Yin

  • Jiezhi Zhan

  • Xiliang He

  • Zhaohu Yu

  • Yu Sun

  • Shanshan Zhang

  • Huadong Lou

  • May 20, 2026

  • 0 min

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Clinical Report: Challenging the Diagnostic Significance of Retrobulbar Spot Sign

Overview

This report presents three cases where the retrobulbar spot sign (RBSS) was detected without confirmed central retinal artery occlusion (CRAO). The findings suggest that RBSS may not be specific to CRAO, indicating a need for further investigation into its diagnostic significance.

Background

Central retinal artery occlusion (CRAO) is a critical ophthalmic emergency that requires prompt diagnosis and treatment. The retrobulbar spot sign (RBSS) has been traditionally associated with CRAO, but its presence in non-CRAO cases raises questions about its diagnostic specificity. Understanding the implications of RBSS in various ocular conditions is essential for accurate diagnosis and management.

Data Highlights

RBSS was detected in all three patients, with only one confirmed case of CRAO. The other two cases exhibited RBSS without CRAO, indicating that RBSS can occur independently of acute ischemic events.

Key Findings

  • RBSS was observed in all three patients studied.
  • Only one patient had confirmed CRAO, while the other two had RBSS without CRAO.
  • RBSS was detected in both eyes of the CRAO patient, despite one eye showing normal function.
  • RBSS can coexist with chronic hypertensive ocular disease, as seen in one case of primary angle-closure glaucoma.
  • Transorbital sonography demonstrated unchanged RBSS findings during follow-up in all four eyes.

Clinical Implications

Clinicians should be cautious in interpreting RBSS as definitive evidence of CRAO, as it may also appear in non-ischemic conditions. Further research is needed to clarify the diagnostic significance of RBSS and its implications for patient management.

Conclusion

The presence of RBSS in non-CRAO cases challenges its traditional diagnostic role, highlighting the need for further studies to understand its implications in various ocular pathologies.

Related Resources & Content

  1. American Academy of Ophthalmology, PubMed, 2025 -- Retinal and Ophthalmic Artery Occlusions Preferred Practice Pattern®
  2. Medical Xpress, 2026 -- Intravenous tenecteplase not recommended for central retinal artery occlusion
  3. Optometric Management, 2025 -- Case Study: Electroretinography in Diabetic Retinopathy
  4. Optometric Management, 2026 -- Neo or Not Neo? Widefield OCT-A Reveals Hidden Neovascularization
  5. Ophthalmology Management, 2017 -- ‘Real world’ OCT: Subtle findings, critical implications
  6. Retinal Physician — Photo Essay
  7. Retinal and Ophthalmic Artery Occlusions Preferred Practice Pattern® - PubMed
  8. Intravenous tenecteplase not recommended for central retinal artery occlusion
  9. Frontiers | Central retinal artery occlusion or retinal stroke: a neurosonologist’s perspective

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