Evaluation of eradication efficacy and optimization strategies for Helicobacter pylori infection based on real-world data: a multivariable retrospective study - Report - MDSpire

Evaluation of eradication efficacy and optimization strategies for Helicobacter pylori infection based on real-world data: a multivariable retrospective study

  • By

  • Ziqi He

  • Linde He

  • Yaliu Qu

  • Yiting Zheng

  • Leyi Dou

  • Shijuan Luo

  • Zhenhao Ye

  • Chaoyuan Huang

  • July 1, 2026

  • 0 min

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Clinical Report: Assessment of Treatment Effectiveness for H. pylori Infection

Overview

This study evaluates the eradication efficacy of various H. pylori treatment regimens using real-world data.

Background

Helicobacter pylori infection is prevalent globally and is a major risk factor for gastric diseases, including cancer. Effective eradication of H. pylori is crucial for alleviating symptoms and reducing cancer risk. However, rising antibiotic resistance complicates treatment effectiveness.

Data Highlights

RegimenITT Eradication RatePP Eradication Rate
Quadruple Therapy81.42%93.76%
Dual TherapyData not reportedData not reported
Triple TherapyData not reportedData not reported

Key Findings

  • Overall ITT eradication rate was 79.04% and PP rate was 90.23%.
  • Quadruple therapy had the highest eradication rates among treatment regimens.
  • Prescription appropriateness significantly influenced eradication success in the quadruple therapy group (p < 0.01).
  • Female patients had a higher eradication success rate in the quadruple therapy group (OR = 2.53).
  • Older patients and those using traditional Chinese medicine showed better follow-up compliance.

Clinical Implications

Clinicians should prioritize guideline-recommended regimens for H. pylori treatment to improve eradication rates. Attention to prescription appropriateness is essential, particularly in the use of quadruple therapy.

Conclusion

The study highlights variability in treatment effectiveness among different regimens.

Related Resources & Content

  1. Tan et al., The Lancet, 2022 -- Helicobacter pylori Eradication and Treatment Efficacy
  2. Frontiers in Gastroenterology, 2026 -- Helicobacter pylori eradication: a narrative review
  3. the new gastroenterologist, 2026 -- No payoff found from higher doses in H. pylori treatment
  4. Treatment of Helicobacter pylori Infection | Gastroenterology | JAMA, 2026
  5. Frontiers in Medicine — Mechanism-matched Helicobacter pylori treatment in the potassium-competitive acid blocker era
  6. Treatment of Helicobacter pylori Infection | Gastroenterology | JAMA | JAMA Network
  7. Comparative Effectiveness of Empiric Treatment for Helicobacter pylori in a Large, Diverse Population in the United States - PubMed
  8. Efficacy and safety of vonoprazan-amoxicillin dual therapy versus bismuth-containing quadruple therapy for patients with Helicobacter pylori infection: a meta-analysis

Original Source(s)

Evaluation of eradication efficacy and optimization strategies for Helicobacter pylori infection based on real-world data: a multivariable retrospective study

  • by Ziqi He, Linde He, Yaliu Qu, Yiting Zheng, Leyi Dou, Shijuan Luo, Zhenhao Ye, Chaoyuan Huang

  • July 1, 2026

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