Linear dose-response relationship between TyG-WC index and diastolic dysfunction: insights from restricted cubic spline and machine learning analysis - Report - MDSpire
Advertisement
Association of TyG-WC Index with Diastolic Dysfunction: A Comprehensive Analysis Using Restricted Cubic Spline and Machine Learning Techniques
Clinical Report: Association of TyG-WC Index with Diastolic Dysfunction
Overview
This study evaluates the association between the triglyceride-glucose waist circumference (TyG-WC) index and diastolic dysfunction (DD) in a community-based population. Findings indicate that elevated TyG-WC is independently linked to an increased risk of DD.
Background
Diastolic dysfunction is a significant precursor to heart failure, particularly heart failure with preserved ejection fraction (HFpEF). The TyG-WC index, which combines metabolic markers with waist circumference, offers a comprehensive assessment of cardiometabolic stress.
Data Highlights
Measure
Value
Odds Ratio (TyG-WC)
1.002 (95% CI: 1.001-1.004, P < 0.001)
High TyG-WC Group Odds Ratio
1.656 (95% CI: 1.266-2.166, P < 0.001)
AUC of Predictive Model
0.687
Key Findings
TyG-WC is independently associated with increased risk of diastolic dysfunction (OR = 1.002).
Individuals with high TyG-WC (≥776.5) have a significantly higher risk of DD (OR = 1.656).
There is a significant linear dose-response relationship between TyG-WC and DD risk (Poverall<0.001).
The predictive model for DD risk using TyG-WC achieved an AUC of 0.687.
Subgroup analyses revealed significant interactions with hypertension and diabetes status.
Machine learning techniques confirmed TyG-WC as an independent contributor to DD risk.
Clinical Implications
The TyG-WC index may serve as a practical marker for identifying individuals at risk of diastolic dysfunction.
Conclusion
Elevated TyG-WC is significantly associated with an increased risk of diastolic dysfunction.
