Premenstrual syndrome, premenstrual dysphoric disorder, and coping strategies in women with menstrual migraine - Report - MDSpire

Premenstrual syndrome, premenstrual dysphoric disorder, and coping strategies in women with menstrual migraine

  • By

  • Alshimaa S. Othman

  • Mona Hussein

  • Alaa Elmazny

  • Salsabil Abo Al-Azayem

  • Azza Elashiry

  • Mennat-Allah Tarek

  • Heba Qassim Shamardal

  • Sara El-Sayed Abd El-Ghani

  • Mohamed Wagdy

  • Eman Hany Elsebaie

  • Doaa Lotfy Abd El Baky

  • Rehab Magdy

  • May 29, 2026

  • 0 min

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Coping Mechanisms and Severity of Premenstrual Syndrome and Dysphoric Disorder

Overview

This study investigates the severity of premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD) in women with menstrual migraine (MM) compared to those without. It highlights the impact of coping strategies on headache severity, revealing that maladaptive strategies correlate with increased headache burden.

Background

Premenstrual syndrome (PMS) affects a significant portion of menstruating women, with severe cases leading to premenstrual dysphoric disorder (PMDD). Understanding the relationship between PMS, PMDD, and menstrual migraine is crucial for developing effective management strategies. This study addresses a gap in research regarding coping mechanisms and their influence on headache severity in women experiencing menstrual migraine.

Data Highlights

GroupPSST ScoreHIT-6 ScorePMDD Diagnosis
Menstrual Migraine (MM)HigherHigher5.6%
Non-Menstrual MigraineLowerLower1.9%

Key Findings

  • Women with MM had significantly higher PSST and HIT-6 scores compared to non-MM women (p = 0.001, 0.002).
  • PMDD was diagnosed in 5.6% of women with MM versus 1.9% in non-MM (p = 0.06).
  • Each PMDD diagnosis was associated with an increase of 3.113 points in HIT-6 scores (95%CI: 0.607–5.915, p = 0.016).
  • Higher PSST scores correlated with higher HIT-6 scores (p ≤ 0.001).
  • Lower awareness and acceptance coping scores were linked to increased headache burden (p ≤ 0.001).

Clinical Implications

Healthcare providers should assess coping strategies in women with menstrual migraine, as maladaptive strategies may exacerbate headache severity. Identifying and promoting effective coping mechanisms could improve patient outcomes and reduce the perceived headache burden.

Conclusion

The study underscores the importance of addressing coping strategies in women with menstrual migraine, particularly those with PMDD, to mitigate headache severity and enhance quality of life.

Related Resources & Content

  1. JAMA Network Open, 2023 -- Bidirectional Association Between Premenstrual Disorders and Psychiatric Disorders
  2. BMC Psychiatry (Springer), 2025 -- Trait- versus state- grey matter volume alterations in premenstrual dysphoric disorder
  3. conexiant, 2023 -- Premenstrual Disorders Linked to Broad Psychiatric Risk
  4. BMC Psychiatry (Springer), 2025 -- Prevalence of migraine among adults with mood disorders: a Saudi cross-sectional study
  5. ICHD-3 -- A1.1.2 Menstrually-related migraine without aura
  6. The Journal of Headache and Pain, 2024 -- Acute and preventive treatment of menstrual migraine: a meta-analysis
  7. Cochrane, 2023 -- What are the benefits and risks of treating premenstrual syndrome and premenstrual dysphoric disorder with selective serotonin reuptake inhibitors?
  8. A1.1.2 Menstrually-related migraine without aura - ICHD-3
  9. Acute and preventive treatment of menstrual migraine: a meta-analysis | The Journal of Headache and Pain | Full Text
  10. What are the benefits and risks of treating premenstrual syndrome and premenstrual dysphoric disorder with selective serotonin reuptake inhibitors? | Cochrane

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