Accelerated Epigenetic and Inflammatory Aging and Intrinsic Capacity - Report - MDSpire

Rapid Epigenetic and Inflammatory Aging Alongside Intrinsic Capacity

  • By

  • Laure Rouch

  • Philipe De Souto Barreto

  • Yves Rolland

  • Sophie Guyonnet

  • Philippe Cestac

  • Wan-Hsuan Lu

  • Jean-Marc Lemaitre

  • Paul Bensadoun

  • David Furman

  • Bruno Vellas

  • Sandrine Andrieu

  • IHU HealthAge INSPIRE/Open Science group

  • Lauréane Brigitte

  • Agathe Milhet

  • Elodie Paez

  • Emeline Muller

  • Sabine Le Floch

  • Catherine Takeda

  • Catherine Faisant

  • Françoise Lala

  • Gabor Abellan Van Kan

  • Zara Steinmeyer

  • Antoine Piau

  • Tony Macaron

  • Davide Angioni

  • Pierre-Jean Ousset

  • Mélanie Comté

  • Nathalie Daniaud

  • Fanny Boissou-Parachaud

  • Christelle Cantet

  • Fabien Pillard

  • Bernard Teysseyre

  • Marie Faruch

  • Pierre Payoux

  • Neda Tavassoli

  • Maria Eugenia Soto

  • Marie Dorard

  • Bénédicte Razat

  • Camille Champigny

  • Cédric Dray

  • Jean-Philippe Pradère

  • Angelo Parini

  • Yohan Santin

  • Dominique Langin

  • Pierre Gourdy

  • Laurent O. Martinez

  • Anne Bouloumié

  • Nicolas Fazilleau

  • Roland Liblau

  • Jean-Charles Guéry

  • Michel Simon

  • Nicolas Gaudenzio

  • Luciana Bostan

  • Hicham El Costa

  • Nabila Jabrane Ferrat

  • Philippe Valet

  • Isabelle Ader

  • Valérie Planat

  • Louis Casteilla

  • Patrice Peran

  • Cyrille Delpierre

  • Claire Rampon

  • Noelie Davezac

  • Bruno Guiard

  • Nathalie Vergnolle

  • Jean-Paul Motta

  • Sara Djebali

  • Pauline Floch

  • Céline Deraison

  • Chrystelle Bonnart

  • Jean-Emmanuel Sarry

  • Nicola Coley

  • Jessica Pontary

  • July 20, 2026

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Clinical Report: Rapid Epigenetic and Inflammatory Aging Alongside Intrinsic Capacity

Overview

This study investigates the associations between biological aging and intrinsic capacity (IC) in a cohort of 1120 participants aged 20 years and older. It examines epigenetic and inflammatory aging clocks as potential biomarkers for assessing functional ability in older adults.

Background

As the global population ages, the prevalence of chronic conditions and functional decline increases. The World Health Organization emphasizes intrinsic capacity (IC) in maintaining well-being in older age. Identifying biomarkers of biological aging, such as epigenetic and inflammatory aging clocks, may provide insights into physiological changes that precede functional decline.

Data Highlights

No numerical data or trial data provided in the source material.

Key Findings

  • The study utilized a cohort of 1120 participants aged 20 years and older to explore the relationship between biological aging and IC.
  • Epigenetic aging was assessed using various DNA methylation clocks, with age acceleration calculated as the residuals from a regression model.
  • Inflammatory aging was measured using serum samples analyzed through a Luminex assay.
  • Associations between accelerated biological aging and IC were examined cross-sectionally and longitudinally.
  • The study aimed to explore domain-specific IC and potential differences in associations by sex.
  • Interactions between epigenetic and inflammatory aging in relation to IC were also investigated.

Clinical Implications

Understanding the relationship between biological aging and intrinsic capacity may aid in identifying individuals at risk for functional decline. This knowledge can inform preventive strategies and interventions aimed at promoting healthy aging.

Conclusion

The findings from this study contribute to the understanding of how biological aging impacts functional ability, highlighting the need for further research in this area.

Related Resources & Content

  1. World Health Organization, Integrated care for older people (ICOPE): guidance for person-centred assessment and pathways in primary care, 2nd ed
  2. An Expert Consensus Statement on Biomarkers of Aging for Use in Intervention Studies - PubMed
  3. Biological age measured by DNA methylation clocks and frailty: a systematic review and meta-analysis - PubMed
  4. Brain — Epigenetic age acceleration in peripheral blood correlates with brain-MRI age acceleration
  5. Archives of Toxicology — Exploring the Impact of Nanomedicine on Reducing Inflammation, Oxidative Stress, and Cellular Aging in Chronic Obstructive Pulmonary Disease
  6. JAMA Network Open — Structural Disadvantage in Adolescence and Biological Aging in Early Midlife
  7. Frontiers in Immunology — Editorial: Immunosenescence and inflammaging: modulating immune function through diet, lifestyle, and therapeutic interventions
  8. Integrated care for older people (‎ICOPE)‎: guidance for person-centred assessment and pathways in primary care, 2nd ed
  9. An Expert Consensus Statement on Biomarkers of Aging for Use in Intervention Studies - PubMed
  10. Biological age measured by DNA methylation clocks and frailty: a systematic review and meta-analysis - PubMed

Original Source(s)

Accelerated Epigenetic and Inflammatory Aging and Intrinsic Capacity

  • by Laure Rouch, Philipe De Souto Barreto, Yves Rolland, Sophie Guyonnet, Philippe Cestac, Wan-Hsuan Lu, Jean-Marc Lemaitre, Paul Bensadoun, David Furman, Bruno Vellas, Sandrine Andrieu, IHU HealthAge INSPIRE/Open Science group, Lauréane Brigitte, Agathe Milhet, Elodie Paez, Emeline Muller, Sabine Le Floch, Catherine Takeda, Catherine Faisant, Françoise Lala, Gabor Abellan Van Kan, Zara Steinmeyer, Antoine Piau, Tony Macaron, Davide Angioni, Pierre-Jean Ousset, Mélanie Comté, Nathalie Daniaud, Fanny Boissou-Parachaud, Christelle Cantet, Fabien Pillard, Bernard Teysseyre, Marie Faruch, Pierre Payoux, Neda Tavassoli, Maria Eugenia Soto, Marie Dorard, Bénédicte Razat, Camille Champigny, Cédric Dray, Jean-Philippe Pradère, Angelo Parini, Yohan Santin, Dominique Langin, Pierre Gourdy, Laurent O. Martinez, Anne Bouloumié, Nicolas Fazilleau, Roland Liblau, Jean-Charles Guéry, Michel Simon, Nicolas Gaudenzio, Luciana Bostan, Hicham El Costa, Nabila Jabrane Ferrat, Philippe Valet, Isabelle Ader, Valérie Planat, Louis Casteilla, Patrice Peran, Cyrille Delpierre, Claire Rampon, Noelie Davezac, Bruno Guiard, Nathalie Vergnolle, Jean-Paul Motta, Sara Djebali, Pauline Floch, Céline Deraison, Chrystelle Bonnart, Jean-Emmanuel Sarry, Nicola Coley, Jessica Pontary

  • July 20, 2026

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