Correlations of systemic immune-inflammation index and systemic inflammation response index with the risk for early-onset post-stroke depression in patients with minor stroke: a prospective observational study - Report - MDSpire

Correlations of systemic immune-inflammation index and systemic inflammation response index with the risk for early-onset post-stroke depression in patients with minor stroke: a prospective observational study

  • By

  • Wei Zhao

  • Mingzhu Deng

  • Zhen Wang

  • Guohua He

  • Wei Xu

  • Tieqiao Feng

  • Jian Peng

  • Kangping Song

  • Ling Xiao

  • Fangyi Li

  • July 6, 2026

  • 0 min

Share

Clinical Report: Associations Between SII, SIRI, and Early-Onset Post-Stroke Depression

Overview

This study investigates the relationship between systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI) with early-onset post-stroke depression (PSD) in minor stroke patients. Findings indicate that both SII and SIRI are associated with early-onset PSD, with correlations to depression severity.

Background

Post-stroke depression (PSD) is a common neuropsychiatric complication following ischemic stroke, affecting approximately one-third of stroke survivors. Early-onset PSD, occurring within the first two weeks post-stroke, is associated with worse clinical outcomes.

Data Highlights

MeasureValue
Patients with early-onset PSD372 (33.42%)
Correlation with SII (r)0.440 (p < 0.001)
Correlation with SIRI (r)0.418 (p < 0.001)
SII OR (95% CI)1.762 (1.261–1.946, p < 0.001)
SIRI OR (95% CI)1.672 (1.348–1.932, p = 0.004)
AUC for SII0.767
AUC for SIRI0.718
AUC for combined indices0.807

Key Findings

  • 33.42% of patients diagnosed with early-onset PSD.
  • Significant positive correlation between HAMD-17 scores and SII (r = 0.440, p < 0.001).
  • Significant positive correlation between HAMD-17 scores and SIRI (r = 0.418, p < 0.001).
  • SII and SIRI are independent predictors of early-onset PSD (OR = 1.762 and OR = 1.672, respectively).
  • AUC for SII, SIRI, and their combination were 0.767, 0.718, and 0.807, respectively.

Clinical Implications

The findings indicate that SII and SIRI are associated with early-onset PSD.

Conclusion

SII and SIRI may serve as tools for predicting early-onset PSD in minor stroke patients.

Related Resources & Content

  1. Frontiers in Psychiatry, 2026 -- The association between systemic immune-inflammation index and post-stroke depression: a meta-analysis
  2. Frontiers in Neurology, 2026 -- Systemic immune-inflammation index predicts post-thrombectomy outcomes and reveals a mediating role in the association between neurocardiac stress and prognosis: a multicenter study
  3. Frontiers in Neurology, 2026 -- Prognostic value of systemic inflammation response index in successfully recanalized acute large vessel occlusion stroke patients: a retrospective study
  4. BPR08 Introduction, Heart and Stroke Foundation -- Post-stroke depression screening and assessment
  5. VA DoD CPG for Management of Stroke Rehabilitation, 2024 -- Clinical Practice Guideline
  6. Frontiers in Neurology — Cardiometabolic index and modified cardiometabolic index are associated with early neurological deterioration in patients with acute ischemic stroke
  7. Correlation analysis of inflammatory markers with the short-term prognosis of acute ischaemic stroke
  8. BPR08 Introduction
  9. VA DoD CPG for Management of Stroke Rehabilitation

Original Source(s)

Correlations of systemic immune-inflammation index and systemic inflammation response index with the risk for early-onset post-stroke depression in patients with minor stroke: a prospective observational study

  • by Wei Zhao, Mingzhu Deng, Zhen Wang, Guohua He, Wei Xu, Tieqiao Feng, Jian Peng, Kangping Song, Ling Xiao, Fangyi Li

  • July 6, 2026

Related Content

Intra-cardiac thrombus detection by electrocardiogram-gated cardiac computed tomography in hyperacute ischemic stroke

Effect of transcranial magnetic stimulation on the limb function of stroke patients: a systematic review and meta-analysis

In-Stent Stenosis or Occlusion After Carotid Artery Stenting in Patients Treated With Anticoagulants vs Antiplatelet Therapy