Clinical Report: Cutaneous SCC Trends Across Sex and Age

Overview

A nationwide study in Denmark involving 109,787 histologically confirmed cases from 2005 to 2023 revealed that incidence rates of carcinoma in situ increased at a faster rate than invasive cutaneous squamous cell carcinoma (cSCC). The study highlights significant differences in incidence trends based on sex and age, with notable increases in both carcinoma in situ and cSCC, particularly among older populations.

Background

Understanding the trends in cutaneous squamous cell carcinoma (cSCC) and carcinoma in situ is crucial for public health and clinical practice, as these skin cancers are among the most common malignancies. The rising incidence rates, particularly in certain demographics, underscore the need for targeted prevention and early detection strategies. This study provides valuable insights into the changing landscape of skin cancer incidence over nearly two decades.

Data Highlights

Key Findings

• Incidence rates for cSCC reached 131.6 per 100,000 person-years in males and 77.7 in females by 2023.
• Carcinoma in situ incidence increased significantly, with rates of 89.4 in males and 78.6 in females.
• Annual percentage increases for carcinoma in situ were 6.4% in males and 5.8% in females.
• Keratoacanthoma incidence declined, with rates around 28 per 100,000 person-years for both sexes.
• Female patients aged 40 to 59 years showed higher incidence rates than males across all neoplasm types starting around 2012.
• Incidence trends varied significantly by anatomical site, with cSCC and carcinoma in situ most frequently affecting the face, scalp, and neck in males, while females had higher rates on lower limbs.

Clinical Implications

The rising incidence of cSCC and carcinoma in situ, particularly among older adults and specific anatomical sites, necessitates enhanced screening and preventive measures. Clinicians should be vigilant in monitoring high-risk populations, including older men and those with immunosuppression, to improve early detection and management outcomes.

Conclusion

This study highlights the increasing burden of cutaneous squamous cell carcinoma and carcinoma in situ, emphasizing the need for targeted public health strategies and clinical vigilance. Continued monitoring of incidence trends is essential for effective prevention and treatment efforts, and further research is needed to address the limitations noted.

References

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