Reversing Epigenetic Changes in Skin Aging to Enhance Longevity Across Various Ethnicities and Skin Types with a Dihydromyricetin-Enriched Serum: Findings from a Prospective Cohort Investigation - Report - MDSpire

Reversing Epigenetic Changes in Skin Aging to Enhance Longevity Across Various Ethnicities and Skin Types with a Dihydromyricetin-Enriched Serum: Findings from a Prospective Cohort Investigation

  • By

  • Minyue Qi

  • Paula Pitta

  • Katrin Wegner

  • Boris Kristof

  • Yan Feng

  • Günter Raddatz

  • Manuel Rodríguez-Paredes

  • Julia Gallinger

  • Rungsima Wanitphakdeedecha

  • Marc Winnefeld

  • Lilia Guadanhim

  • Cheri Frey

  • Frank Lyko

  • Cassandra Falckenhayn

  • Elke Grönniger

  • April 25, 2026

  • 0 min

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Clinical Report: Reversing Epigenetic Changes in Skin Aging with DHM Serum

Overview

This study demonstrates that epigenetic aging signatures are conserved across various ethnicities and that a dihydromyricetin-enriched serum can effectively reverse biological skin age. The findings support the use of epigenetic rejuvenation strategies for enhancing skin longevity across diverse populations.

Background

Understanding skin aging mechanisms across different ethnicities is crucial for developing effective anti-aging interventions. Traditional research has predominantly focused on white populations, neglecting the unique aging characteristics of other ethnicities. This study addresses the gap by exploring the shared epigenetic mechanisms of skin aging and the potential of dihydromyricetin as a rejuvenating agent.

Data Highlights

No numerical data provided in the source material.

Key Findings

  • Epigenetic aging mechanisms are conserved across diverse ethnicities and skin types.
  • A topical formulation containing dihydromyricetin (DHM) can reverse biological skin age.
  • Visible and structural signs of skin aging improve with DHM application.
  • Epigenetic rejuvenation is proposed as a viable strategy for skin longevity.
  • Understanding of skin aging can lead to optimized interventions for specific ethnicities.

Clinical Implications

Clinicians should consider the role of epigenetic factors in skin aging when developing treatment plans for diverse patient populations. The use of dihydromyricetin-enriched products may offer a novel approach to enhance skin longevity and address visible signs of aging effectively.

Conclusion

This study highlights the importance of recognizing shared epigenetic mechanisms in skin aging across ethnicities and supports the potential of dihydromyricetin as a therapeutic agent for skin rejuvenation.

References

  1. Brain, Epigenetic age acceleration in peripheral blood correlates with brain-MRI age acceleration, 2023 -- https://academic.oup.com/brain/article/148/8/2861/8038010
  2. The ASCO Post, Researchers Find DOPA May Protect Against Melanoma and Identify Potential New Therapeutic Targets to Treat Melanoma, 2022 -- https://ascopost.com/news/september-2022/researchers-find-dopa-may-protect-against-melanoma-and-identify-potential-new-therapeutic-targets-to-treat-melanoma/
  3. The Journal of Clinical Endocrinology & Metabolism, Genetic Factors Linked to Biochemical Reactions to Vitamin D3 in the Multi-Ethnic Study of Atherosclerosis, 2023 -- https://academic.oup.com/jcem/article/110/10/2903/7958167
  4. Personalized Photoprotection: Expert Consensus and Recommendations From a Delphi Study Among Dermatologists, 2025 -- https://www.uniderma.info/wp-content/uploads/2025/02/2025_De-Troya-M_Personalized-Photoprotection-Expert-Consensus_-Photoderm-Photoimmuno-Photomed.pdf
  5. Comparative efficacy of topical interventions for facial photoaging: a network meta-analysis, 2025 -- https://www.nature.com/articles/s41598-025-12597-0
  6. The Journal of Clinical Endocrinology & Metabolism — Investigating the Impact of SGLT2 Inhibitors on Cognitive Function and Aging Through Mendelian Randomization Analysis
  7. Epigenetic age predictors for non-invasive assessment of human skin
  8. Personalized Photoprotection: Expert Consensus and Recommendations From a Delphi Study Among Dermatologists
  9. Comparative efficacy of topical interventions for facial photoaging: a network meta-analysis | Scientific Reports

Original Source(s)

Reversing Epigenetic Changes in Skin Aging to Enhance Longevity Across Various Ethnicities and Skin Types with a Dihydromyricetin-Enriched Serum: Findings from a Prospective Cohort Investigation

  • by Minyue Qi, Paula Pitta, Katrin Wegner, Boris Kristof, Yan Feng, Günter Raddatz, Manuel Rodríguez-Paredes, Julia Gallinger, Rungsima Wanitphakdeedecha, Marc Winnefeld, Lilia Guadanhim, Cheri Frey, Frank Lyko, Cassandra Falckenhayn, Elke Grönniger

  • April 25, 2026

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