Biological effects of 18F-FDG administration and CT dose during PET/CT: chromosomal aberrations in a two-center prospective observational study - Report - MDSpire

Biological effects of 18F-FDG administration and CT dose during PET/CT: chromosomal aberrations in a two-center prospective observational study

  • By

  • Yuri Kawashima

  • Yasuha Kinugasa

  • Mana Ishibashi

  • Wataru Fukumoto

  • Yoshihiro Miyata

  • Reiko Ideguchi

  • Chiemi Sakai

  • Mari Ishida

  • Seiko Hirota

  • Shinji Yoshinaga

  • Ikuno Nishibuchi

  • Yuji Murakami

  • Gloriamaris Loy-Caraos

  • Namkhai Bayasgalan

  • Suvd Bayarjargal

  • Lin Shi

  • Jiying Sun

  • Yasunori Horikoshi

  • Morihito Okada

  • Yuko Nakamura

  • Kazuo Awai

  • Takashi Kudo

  • Satoshi Tashiro

  • July 17, 2026

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Impact of 18F-FDG Administration and CT Radiation Exposure on Chromosomal Aberrations

Overview

This study investigates the acute biological effects of internal 18F-FDG and external CT radiation exposure on chromosomal aberrations (CAs) in patients undergoing PET/CT.

Background

18F-FDG-PET/CT is widely used for cancer detection, yet concerns about radiation exposure persist due to the combination of internal and external radiation sources. Current guidelines lack consensus on optimal CT dose settings.

Data Highlights

No numerical data or trial results were provided in the source material.

Key Findings

  • The study utilized a high-sensitivity chromosomal aberration assay to assess radiation exposure effects.
  • Patients were enrolled from two centers with differing CT dose protocols: reduced-dose and standard-dose.
  • Chromosomal aberrations serve as robust biomarkers for evaluating radiation-associated cancer risk.
  • Previous studies indicated that reduced-dose CT protocols may have biological advantages over standard-dose protocols.
  • Internal FDG exposure and external CT radiation may interact, impacting chromosomal aberration rates.

Clinical Implications

The findings highlight the importance of evaluating radiation exposure from both FDG and CT components in PET/CT imaging.

Conclusion

This study provides insights into the biological effects of radiation exposure in PET/CT.

Related Resources & Content

  1. European Radiology, 2022 -- Early Insights into the Use of Abdominal Photon-Counting Computed Tomography in Clinical Practice: Image Quality Assessment and Radiation Dose Evaluation
  2. European Radiology, 2023 -- Advancements Over Two Decades in Pediatric Imaging Using a Reduced Dose of [18F]Fluorodeoxyglucose PET/CT and PET/MR Techniques
  3. Gastric Cancer, 2018 -- The Role of Histological Variants in the Clinical Significance of FDG-PET/CT for Advanced Gastric Cancer
  4. The SNMMI/ACNM Practice Guideline for the Use of Radiopharmaceuticals 5.0 - PubMed
  5. Journal of Neuro-Oncology — Evaluation of 18 F-fluciclovine PET Imaging for Monitoring Glioblastoma Tumor Volumes Throughout Surgical and Radiotherapeutic Interventions
  6. The SNMMI/ACNM Practice Guideline for the Use of Radiopharmaceuticals 5.0 - PubMed
  7. Frequency of γ-H2AX foci, micronucleus formation, and radiation dose to the blood lymphocytes in pediatric and adult participants underwent computed tomography imaging - ScienceDirect

Original Source(s)

Biological effects of 18F-FDG administration and CT dose during PET/CT: chromosomal aberrations in a two-center prospective observational study

  • by Yuri Kawashima, Yasuha Kinugasa, Mana Ishibashi, Wataru Fukumoto, Yoshihiro Miyata, Reiko Ideguchi, Chiemi Sakai, Mari Ishida, Seiko Hirota, Shinji Yoshinaga, Ikuno Nishibuchi, Yuji Murakami, Gloriamaris Loy-Caraos, Namkhai Bayasgalan, Suvd Bayarjargal, Lin Shi, Jiying Sun, Yasunori Horikoshi, Morihito Okada, Yuko Nakamura, Kazuo Awai, Takashi Kudo, Satoshi Tashiro

  • July 17, 2026

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