Maternal Intellectual and Developmental Disabilities and Infant Outcomes - Report - MDSpire

Maternal Intellectual and Developmental Disabilities and Infant Outcomes

  • By

  • Catherine Psaras

  • Rita H. Ryu

  • Rebecca Baer

  • Kristin Palmsten

  • Lori Kroh

  • Jeanne Townsend

  • Jaime Barea

  • Jerasimos Ballas

  • Gretchen Bandoli

  • May 27, 2026

  • 0 min

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Clinical Report: Impact of Maternal Intellectual and Developmental Disabilities on Infant Health Outcomes

Overview

This study investigates the associations between maternal intellectual and developmental disabilities (IDDs) and adverse infant health outcomes, including preterm birth and NICU admissions. It highlights significant risks associated with various IDD subtypes and emphasizes the need for targeted interventions.

Background

Intellectual and developmental disabilities (IDDs) affect approximately 1% to 2% of the population and are linked to poorer health outcomes during pregnancy. Previous studies have indicated increased risks of adverse birth outcomes for infants born to mothers with IDDs, but limitations in these studies have hindered clinical application. Understanding these associations is crucial for improving maternal and infant health care.

Data Highlights

OutcomeRisk Increase
Preterm Birth50% to 80%
NICU Admission50% to 80%
Small-for-Gestational-Age BirthNot specified

Key Findings

  • Maternal IDDs are associated with a 50% to 80% increased risk of preterm birth and NICU admission.
  • Distinct IDD subtypes (ASD, ID, CP, chromosomal differences) were analyzed for their specific impacts on infant outcomes.
  • Previous studies aggregated IDD subtypes, potentially obscuring the true effects on infant health.
  • Causal mediation analyses were employed to estimate the proportion of excess risk associated with modifiable maternal characteristics.
  • The study utilized a comprehensive dataset from California, linking vital statistics with hospital records.

Clinical Implications

Healthcare providers should be aware of the increased risks associated with maternal IDDs and consider these factors when managing pregnancies. Targeted interventions may be necessary to address modifiable maternal characteristics that contribute to adverse infant outcomes.

Conclusion

The findings underscore the importance of understanding the impact of maternal IDDs on infant health outcomes, highlighting the need for tailored clinical approaches.

Related Resources & Content

  1. Rubenstein et al, Wisconsin Medicaid, 2007-2016 -- Maternal IDDs and Infant Outcomes
  2. Akobirshoev et al, Nationwide Inpatient Sample, 2007-2011 -- Maternal IDDs and Preterm Birth
  3. The Journal of Clinical Endocrinology & Metabolism — Association of Maternal Thyroglobulin With Gestational Thyroid Function and Offspring IQ and Brain Morphology
  4. The Journal of Clinical Endocrinology & Metabolism — Link Between Reduced Maternal Sleep Duration and Neurodevelopmental Delays in Children: Findings from a Prospective Cohort Study
  5. the pathologist — Why Maternal Co-morbidities Matter for Newborn Care
  6. the asco post — Eliminating Barriers to Care for Patients With Intellectual and/or Developmental Disabilities
  7. Access to Obstetric and Gynecologic Care for Patients With Disabilities | ACOG
  8. Pregnancy and postnatal outcomes for women with intellectual disability and their infants: A systematic review
  9. Acetaminophen Use in Pregnancy and Neurodevelopmental Outcomes | ACOG
  10. Maternal Disability and Emergency Department Use for Infants | Pediatrics | JAMA Network Open | JAMA Network
  11. Pregnancy Outcomes Among Individuals With Cerebral Palsy: A Population-Based Cohort Study - PubMed

Original Source(s)

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