Relationship Between the sdLDL-C/lbLDL-C Ratio and Heart Failure
Overview
This study investigates the association between LDL subfractions and heart failure (HF) risk. The sdLDL-C/lbLDL-C ratio was identified as an independent factor associated with HF.
Background
Heart failure is a leading cause of morbidity and mortality worldwide, particularly among older adults. Dyslipidemia is a recognized risk factor for cardiovascular diseases, including HF, yet the specific roles of LDL subfractions in HF remain inadequately explored.
Data Highlights
Parameter
HF Patients (n=584)
Controls (n=611)
sdLDL-C
Higher
Lower
lbLDL-C
Lower
Higher
sdLDL-C/lbLDL-C Ratio
Higher
Lower
Key Findings
HF patients exhibited significantly higher sdLDL-C levels compared to controls.
HF patients had lower lbLDL-C levels than controls.
The sdLDL-C/lbLDL-C ratio was significantly higher in HF patients.
Multivariable logistic regression identified the sdLDL-C/lbLDL-C ratio as an independent factor associated with HF (OR = 2.199, P < 0.001).
Conventional LDL-C levels did not significantly differ between HF patients and controls.
Clinical Implications
Evaluating the sdLDL-C/lbLDL-C ratio may provide insights into heart failure risk beyond traditional LDL-C measurements.
Conclusion
The study emphasizes the association of LDL subfraction profiles with heart failure risk and the sdLDL-C/lbLDL-C ratio.
