Research on the construction of prediction model for depressive symptom in the second and third trimester of pregnancy based on artificial neural network - Report - MDSpire

Research on the construction of prediction model for depressive symptom in the second and third trimester of pregnancy based on artificial neural network

  • By

  • Wang, Liuyue

  • Zhou, Dandan

  • Liu, Yanhui

  • Liu, Zhiqun

  • Wan, Huan

  • April 29, 2026

  • 0 min

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Clinical Report: Predictive Model for Depressive Symptoms in Pregnancy

Overview

This study developed an artificial neural network-based model to predict depressive symptoms in pregnant women during the second and third trimesters. The model achieved a prediction accuracy of 86.9%, highlighting significant correlations between various psychosocial factors and depressive symptoms.

Background

Prenatal depression is a critical public health concern, affecting approximately 20.7% of pregnant women globally. Identifying and addressing depressive symptoms during pregnancy is essential for maternal and fetal health. This study aims to enhance early screening and targeted interventions for pregnant women at risk of depression.

Data Highlights

MeasureValue
Positive rate of depressive symptoms42.7%
Prediction accuracy of logistic regression model79.6%
Prediction accuracy of neural network model86.9%

Key Findings

  • 42.7% of women screened positive for depressive symptoms in the second and third trimesters.
  • Higher levels of social support and active coping were negatively correlated with depressive symptoms.
  • Negative coping and susceptible personality traits were positively correlated with depressive symptoms.
  • The artificial neural network model outperformed traditional logistic regression in predicting depressive symptoms.
  • Early identification and targeted interventions can be informed by the identified psychosocial factors.

Clinical Implications

Healthcare providers should implement routine screening for depressive symptoms during the second and third trimesters of pregnancy. Understanding the psychosocial factors associated with depression can guide tailored interventions to improve maternal mental health outcomes.

Conclusion

The development of an artificial neural network-based predictive model represents a significant advancement in identifying pregnant women at risk for depressive symptoms. This approach can facilitate early intervention and support for affected individuals.

Related Resources & Content

  1. BMC Psychiatry (Springer), 2025 -- The relationship between self-efficacy and prenatal depression in Chinese pregnant women: a parallel latent growth curve model
  2. Cedars-Sinai Pulse, 2025 -- Machine Learning Used to Predict Postpartum Depression Risk
  3. JMIR Medical Informatics, 2026 -- Adverse Pregnancy Outcomes in Women With Immune Abnormalities: Machine Learning Model Development and Validation Using First-Trimester Sonographic Features
  4. BMC Psychiatry (Springer), 2025 -- Creation, assessment, and illustration of a machine learning-driven model to predict depression risk among patients with sleep disorders
  5. Patient Screening | ACOG, 2025 -- ACOG guidelines on perinatal mental health screening
  6. A Randomized Controlled Trial of a Telehealth Group Intervention to Reduce Perinatal Depressive Symptoms: A Mixed Methods Analysis - PubMed, 2025
  7. Frontiers, 2025 -- Artificial intelligence-oriented predictive model for the risk of postpartum depression: a systematic review
  8. Patient Screening | ACOG
  9. A Randomized Controlled Trial of a Telehealth Group Intervention to Reduce Perinatal Depressive Symptoms: A Mixed Methods Analysis - PubMed
  10. Frontiers | Artificial intelligence-oriented predictive model for the risk of postpartum depression: a systematic review

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