Association of AT1R expression with transplant glomerulopathy and interstitial fibrosis in kidney transplant recipients - Report - MDSpire

Association of AT1R expression with transplant glomerulopathy and interstitial fibrosis in kidney transplant recipients

  • By

  • Katarzyna Jakuszko

  • Piotr Donizy

  • Agnieszka Sas

  • Guido Moll

  • Rusan Catar

  • Renata Trzeciak-Snopczyńska

  • Justyna Zachciał

  • Sławomir Zmonarski

  • Magdalena Kuriata-Kordek

  • Agnieszka Hałoń

  • Maciej Wuczyński

  • Krzysztof Kujawa

  • Dariusz Janczak

  • Mirosław Banasik

  • July 14, 2026

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Clinical Report: Correlation Between AT1R Expression Levels and Transplant Glomerulopathy

Overview

This study investigates the relationship between AT1R expression and the presence of transplant glomerulopathy (TG) and interstitial fibrosis (IF) in kidney transplant patients. Findings indicate that AT1R expression is associated with increased severity of TG and IF.

Background

Chronic allograft dysfunction (CAD) is a significant cause of late kidney transplant failure, influenced by both immune and non-immune mechanisms. Transplant glomerulopathy (TG) and interstitial fibrosis (IF) are critical histopathological features linked to chronic antibody-mediated injury and long-term graft loss. Understanding the role of AT1R in these processes may provide insights into chronic allograft injury.

Data Highlights

ParameterAT1R PositiveAT1R NegativeP-value
Transplant Glomerulopathy24%7%0.042
Interstitial Fibrosis56%27%0.011
IF SeverityHigherLower0.028

Key Findings

  • AT1R expression was found in 44.2% of kidney transplant patients.
  • Patients with positive AT1R expression had significantly higher rates of TG (24% vs. 7%) and IF (56% vs. 27%).
  • Severity of interstitial fibrosis was greater in patients with AT1R expression (p=0.028).
  • Anti-AT1R antibody levels did not differ significantly between AT1R positive and negative groups.
  • Multiple risk factors, including AT1R expression and histopathological lesions, were associated with worse long-term graft survival.

Clinical Implications

The presence of AT1R expression in kidney transplant recipients may indicate a higher risk for developing interstitial fibrosis and transplant glomerulopathy.

Conclusion

AT1R expression correlates with the presence and severity of TG and IF in kidney transplant patients.

Related Resources & Content

  1. Genetic Variants in Nucleotide Factor of Activated T Cells Cytoplasmic 2 and 4 Associated with Acute Rejection Risk After Kidney Transplantation
  2. Prognosis of renal re-transplantation for Chronic Graft Failure
  3. Results of Kidney Transplantation in Patients with AL Amyloidosis: Insights from an International Collaboration by The International Kidney and Monoclonal Gammopathy Research Group
  4. The Banff 2024 Kidney Meeting Report: Rejection as a spectrum of phenotypes and focus on differential diagnostic reasoning
  5. Non-HLA antibodies in kidney transplantation: comprehensive insights and clinical implications
  6. Suboptimal early graft performance negatively affects long-term results in living donor kidney transplants
  7. The Banff 2024 Kidney Meeting Report: Rejection as a spectrum of phenotypes and focus on differential diagnostic reasoning - PubMed
  8. Non-HLA antibodies in kidney transplantation: comprehensive insights and clinical implications - PubMed
  9. The Diversity of Transplant Glomerulitis and its Relationship to Alloantibody - PMC

Original Source(s)

Association of AT1R expression with transplant glomerulopathy and interstitial fibrosis in kidney transplant recipients

  • by Katarzyna Jakuszko, Piotr Donizy, Agnieszka Sas, Guido Moll, Rusan Catar, Renata Trzeciak-Snopczyńska, Justyna Zachciał, Sławomir Zmonarski, Magdalena Kuriata-Kordek, Agnieszka Hałoń, Maciej Wuczyński, Krzysztof Kujawa, Dariusz Janczak, Mirosław Banasik

  • July 14, 2026

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