Immunologically-based nutritional status assessment amongst preoperative colorectal cancer patients – does it link to TNM stage - Report - MDSpire

Immunologically-based nutritional status assessment amongst preoperative colorectal cancer patients – does it link to TNM stage

  • By

  • Karolina Kaźmierczak-Siedlecka

  • Piotr Wiśniewski

  • Robert Kucharski

  • Ewa Stachowska

  • Wojciech Makarewicz

  • July 10, 2026

  • 0 min

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Evaluation of Immunological Nutritional Status in Preoperative Colorectal Cancer Patients

Overview

This study evaluates the immunonutritional status of preoperative colorectal cancer (CRC) patients and its correlation with TNM staging.

Background

Colorectal cancer patients are at high risk for malnutrition, which can adversely affect surgical outcomes. Assessing nutritional status using standardized tools is crucial for identifying malnourished patients.

Data Highlights

ParameterValue
Participants12
T3 Classification67%
Lymph Node Metastasis50%
PNI Low Group34%
PNI High Group66%
Mean Lymphocyte Levels22.03 ± 7.31%

Key Findings

  • 67% of patients were classified as T3 in TNM staging.
  • 50% of patients had lymph node metastasis.
  • Mean lymphocyte levels were reduced in the study population.
  • The optimal cut-off value for PNI was determined to be 51.74.
  • PNI-low was associated with more advanced local disease, though not statistically significant.
  • Lymph node metastasis was more frequent in the PNI-high group.

Clinical Implications

Routine assessment of nutritional status in preoperative CRC patients is essential to identify those at risk of malnutrition.

Conclusion

The study highlights the importance of immunonutritional assessment in preoperative CRC patients and its correlation with TNM staging.

Related Resources & Content

  1. Frontiers in Oncology, 2026 -- Development and validation of a pre-chemotherapy nomogram integrating systemic immune-inflammation index and prognostic nutritional index to predict severe adjuvant toxicity in colorectal cancer
  2. Impact of Immunonutrition on Surgical Outcomes in Colorectal Cancer Patients: A Meta-Analytic Review, 2017
  3. ESPEN guideline on clinical nutrition in surgery – Update 2025
  4. Clinical Practice Guidelines for Enhanced Recovery After Colon and Rectal Surgery From the American Society of Colon and Rectal Surgeons and the Society of American Gastrointestinal and Endoscopic Surgeons, 2023
  5. Frontiers in Oncology — Distinct roles of nutritional and inflammatory signatures in predicting pathological response versus long-term survival in locally advanced gastric cancer treated with neoadjuvant immunotherapy
  6. Determining the Ideal Preoperative Neutrophil–Lymphocyte Ratio Cutoff and Its Impact on Postoperative Outcomes in Colorectal Cancer Patients
  7. ESPEN guideline on clinical nutrition in surgery – Update 2025
  8. Clinical Practice Guidelines for Enhanced Recovery After Colon and Rectal Surgery
  9. Clinical Practice Guidelines for Enhanced Recovery After Colon and Rectal Surgery From the American Society of Colon and Rectal Surgeons and the Society of American Gastrointestinal and Endoscopic Surgeons - PMC
  10. Pre-Operative Immunonutrition Enhances Postoperative Outcomes and Elevates Tumor-Infiltrating Lymphocyte Counts in Colorectal Cancer Patients: A Meta-Analysis of Randomized Controlled Trials - PubMed
  11. Effects of Preoperative Immunonutrition on Postoperative Complications in Patients Undergoing Colorectal Cancer Resection: A Systematic Review and Meta-analysis - PubMed
  12. The use of preoperative enteral immunonutrition in patients undergoing elective colorectal cancer surgery: A systematic review and meta‐analysis - PMC
  13. Effect of preoperative oral nutritional supplements on clinical outcomes in patients undergoing surgery for gastrointestinal cancer: A systematic review and meta-analysis - PMC
  14. Prognostic value and clinicopathological significance of pre-and post-treatment systemic immune-inflammation index in colorectal cancer patients: a meta-analysis - PMC
  15. Prognostic value of Prognostic Nutritional Index in cancer: an umbrella review of systematic review and meta-analysis - PMC
  16. Prognostic value of controlling nutritional status score (CONUT) in patients with colorectal cancer: a systematic review and meta-analysis | BMC Cancer | Springer Nature Link
  17. GLIM consensus approach to diagnosis of malnutrition: A 5‐year update - PMC
  18. Validity of the GLIM criteria for the diagnosis of malnutrition in patients with colorectal cancer: A multicenter study on the diagnostic performance of different indicators of reduced muscle mass and disease severity - ScienceDirect

Original Source(s)

Immunologically-based nutritional status assessment amongst preoperative colorectal cancer patients – does it link to TNM stage

  • by Karolina Kaźmierczak-Siedlecka, Piotr Wiśniewski, Robert Kucharski, Ewa Stachowska, Wojciech Makarewicz

  • July 10, 2026

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