Implantation of XEN‑45 for Treatment of Refractory Secondary Glaucoma - Report - MDSpire

Implantation of XEN‑45 for Treatment of Refractory Secondary Glaucoma

  • By

  • Kun Lv

  • Zhiqiao Liang

  • Kuankuan Wu

  • Yao Ma

  • Kangyi Yang

  • Wenbo Liu

  • Huijuan Wu

  • November 14, 2025

  • 0 min

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Clinical Report: Implantation of XEN‑45 for Treatment of Refractory Secondary Glaucoma

Overview

This study evaluates the efficacy of the XEN-45 gel stent in managing refractory secondary glaucoma (SG) in a Chinese patient population. Results indicate significant intraocular pressure (IOP) reduction and highlight the stent's potential as a viable surgical option when conventional treatments fail.

Background

Glaucoma is a major cause of irreversible vision loss, with secondary glaucoma (SG) being particularly challenging to manage due to its diverse etiologies. Traditional surgical interventions often carry substantial risks, prompting the need for safer alternatives. The XEN-45 gel stent represents a minimally invasive option that may improve outcomes for patients with refractory SG.

Data Highlights

No numerical data available in the provided material.

Key Findings

  • XEN-45 gel stents are effective in managing various forms of refractory secondary glaucoma.
  • The study included patients with diverse etiologies such as uveitic, steroid-induced, and traumatic glaucoma.
  • Minimally invasive techniques like ab externo implantation have gained popularity due to reduced intraocular manipulation.
  • Significant IOP reduction was observed in patients who underwent XEN-45 implantation.
  • Proactive management of blebs is crucial for optimizing surgical outcomes.

Clinical Implications

The XEN-45 gel stent offers a promising alternative for patients with refractory secondary glaucoma who do not respond to medical therapy or previous surgeries. Clinicians should consider this option while being mindful of the need for ongoing bleb management.

Conclusion

The implantation of XEN-45 gel stents demonstrates significant potential in treating refractory secondary glaucoma, warranting further investigation and consideration in clinical practice.

References

  1. Ophthalmology Management, 2018 -- Two Years of Xen: Clinical Experience and Data
  2. Ophthalmology Management, 2021 -- Transforming the glaucoma treatment paradigm
  3. Ophthalmic Professional, 2018 -- Opening Lines
  4. Retinal Physician, 2023 -- SUBSPECIALTY NEWS: Early anti-VEGF for DR shows no benefit, developments in gene therapy, research on IRD, and more.
  5. Advancing glaucoma care: What's new in the 6th edition of the European Glaucoma Society guidelines, 2026
  6. XEN‑45 implantation for refractory secondary glaucoma | BMC Ophthalmology
  7. Effectiveness and safety of the XEN45 gel stent compared to trabeculectomy in primary open-angle glaucoma: the Gold-Standard Pathway Study
  8. Advancing glaucoma care: What's new in the 6th edition of the European Glaucoma Society guidelines - Marta Pazos, Carlo E Traverso, Ananth Viswanathan, Augusto Azuara-Blanco, Luis Abegão Pinto, Ingeborg Stalmans, 2026
  9. XEN‑45 implantation for refractory secondary glaucoma | BMC Ophthalmology | Springer Nature Link
  10. Effectiveness and safety of the XEN45 gel stent compared to trabeculectomy in primary open-angle glaucoma: the Gold-Standard Pathway Study - PMC

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