Risk-Stratified Transitional Care and Cardiovascular Hospitalizations by Sex: A Secondary Analysis of a - Report - MDSpire

Risk-Stratified Transitional Care and Cardiovascular Hospitalizations by Sex: A Secondary Analysis of a

  • By

  • Douglas S. Lee

  • Chang (Nancy) Wang

  • Peter C. Austin

  • Sharon E. Straus

  • Michael E. Farkouh

  • Alice Chong

  • Monica Taljaard

  • Stephanie Poon

  • Stuart Smith

  • Robert S. McKelvie

  • Robert M. Iwanochko

  • Andrea MacDougall

  • Esam Elbarasi

  • Peter M. Cram

  • Jiming Fang

  • Clare L. Atzema

  • Jacob A. Udell

  • Paula A. Rochon

  • Michael J. Schull

  • Susanna Mak

  • Heather J. Ross

  • May 12, 2026

  • 0 min

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Sex-Based Analysis of Risk-Stratified Transitional Care and Cardiovascular Hospitalization Rates

Overview

This study investigates sex differences in the effectiveness of a risk-stratified transitional care strategy for heart failure patients. It highlights that while both sexes benefit from the intervention, females may experience higher rates of readmission compared to males, emphasizing the need for tailored postdischarge follow-up.

Background

Heart failure (HF) is a significant global health issue, affecting over 64 million individuals and leading to substantial healthcare costs due to frequent hospitalizations. Although men and women have a similar lifetime risk of HF, women often face a greater symptom burden and higher long-term readmission rates. Understanding sex-based differences in HF management is crucial for optimizing care and improving outcomes.

Data Highlights

No numerical data available in the source material.

Key Findings

  • The COACH trial utilized a risk stratification algorithm to guide discharge decisions for acute HF patients.
  • Both male and female patients were included in the COACH trial, but the impact of the intervention on readmission rates may differ by sex.
  • Women are more likely to experience higher rates of readmission when follow-up is less than one year.
  • Effective transitional care strategies are essential to reduce adverse outcomes post-discharge.
  • Research ethics approval was obtained to ensure diverse patient inclusion in the trial.

Clinical Implications

Healthcare providers should consider sex differences when implementing transitional care strategies for heart failure patients. Enhanced follow-up care for female patients may be necessary to mitigate higher readmission rates and improve overall outcomes.

Conclusion

The findings underscore the importance of sex-specific considerations in heart failure management, particularly in transitional care settings. Tailoring follow-up strategies may enhance patient outcomes and reduce readmission rates.

Related Resources & Content

  1. Frontiers in Cardiovascular Medicine, 2026 -- Sex-Related Differences in Conduit Strategy and Early Outcomes After Sternum-Sparing On-Pump Multivessel CABG via Left Anterior Thoracotomy
  2. European Journal of Preventive Cardiology -- Risk stratification for cardiovascular disease: a comparative analysis of cluster analysis and traditional prediction models
  3. Intensive Care Medicine -- Exploring Gender Disparities in Intensive Care Access: A Bayesian Analysis
  4. Clinical Research in Cardiology -- Sex Differences in Presentation, Outcomes, and Management in the Cardiac Intensive Care Unit: Insights from the SPOTlight Study
  5. Hub - 2024 Update to the 2020 ACC/AHA Clinical Performance and Quality Measures for Adults With Heart Failure - American Heart Association
  6. Mobile Integrated Health vs a Transitions of Care Coordinator for Patients Discharged After Heart Failure: The Mighty-Heart Randomized Clinical Trial | JAMA Internal Medicine
  7. Sex differences in pharmacological treatment of heart failure: a meta-analysis of randomized trials | European Heart Journal
  8. Hub - 2024 Update to the 2020 ACC/AHA Clinical Performance and Quality Measures for Adults With Heart Failure - Professional Heart Daily | American Heart Association
  9. Mobile Integrated Health vs a Transitions of Care Coordinator for Patients Discharged After Heart Failure: The Mighty-Heart Randomized Clinical Trial | Heart Failure | JAMA Internal Medicine | JAMA Network
  10. Sex differences in pharmacological treatment of heart failure: a meta-analysis of randomized trials | European Heart Journal | Oxford Academic

Original Source(s)

Risk-Stratified Transitional Care and Cardiovascular Hospitalizations by Sex: A Secondary Analysis of a

  • by Douglas S. Lee, Chang (Nancy) Wang, Peter C. Austin, Sharon E. Straus, Michael E. Farkouh, Alice Chong, Monica Taljaard, Stephanie Poon, Stuart Smith, Robert S. McKelvie, Robert M. Iwanochko, Andrea MacDougall, Esam Elbarasi, Peter M. Cram, Jiming Fang, Clare L. Atzema, Jacob A. Udell, Paula A. Rochon, Michael J. Schull, Susanna Mak, Heather J. Ross

  • May 12, 2026

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