Beyond fluorescence intensity: a Minimum acquisition and reporting standard and emerging technologies for colorectal indocyanine green fluorescence angiography studies - Report - MDSpire

Beyond fluorescence intensity: a Minimum acquisition and reporting standard and emerging technologies for colorectal indocyanine green fluorescence angiography studies

  • By

  • Parvat Kuwar Chhetri

  • Anmol Bhan

  • Kristen K. Rumer

  • David W. Larson

  • July 2, 2026

  • 0 min

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Clinical Report: Advancements in Colorectal Indocyanine Green Fluorescence Angiography

Background

Anastomotic leak (AL) is a significant complication in colorectal surgery, leading to increased morbidity and healthcare costs. ICG-FA has emerged as a tool for intraoperative assessment of bowel perfusion. Recent trials have shown mixed results, highlighting the variability in methodologies used in ICG-FA.

Data Highlights

No numerical data provided in the source material, but qualitative findings indicate variability in ICG-FA effectiveness.

Key Findings

  • ICG-FA is increasingly used to assess bowel perfusion during colorectal anastomosis.
  • Mixed findings from recent multicenter randomized trials indicate variability in the effectiveness of ICG-FA.
  • Visual interpretation of ICG-FA shows substantial interobserver variability, making single fluorescence-intensity snapshots unreliable.
  • Time-intensity kinetics and spatial heterogeneity measures are more reproducible and physiologically meaningful than traditional methods.
  • A proposed minimum acquisition and reporting standard aims to enhance the consistency of ICG-FA studies.
  • Current evidence on the effectiveness of ICG-FA is preliminary and requires multicenter validation.

Clinical Implications

Standardizing ICG-FA acquisition and reporting could enhance the reliability of its use in clinical settings.

Conclusion

The focus should shift from whether to use ICG-FA to how to standardize its acquisition and interpretation.

Related Resources & Content

  1. SAGES, 2025 -- 2025 Guidelines for Fluorescence Image-guided Surgery Using Indocyanine Green in Gastrointestinal Procedures
  2. Surgical Endoscopy, 2025 -- Assessment of Indocyanine Green Fluorescence Angiography in Colorectal Surgical Procedures: A Comprehensive Literature Review
  3. Surgical Endoscopy, 2023 -- Assessment of Bowel Perfusion Using Indocyanine Green Near-Infrared Fluorescence in Colorectal Surgical Procedures
  4. Frontiers in Surgery, 2026 -- Indocyanine green fluorescence angiography in laparoscopic sigmoid and rectal cancer surgery: no reduction in anastomotic leakage but a lower incidence of anastomotic strictures.
  5. Innovative Technique for Evaluating Endoluminal Anastomotic Integrity Using Fluoroangiography Following Left-sided Colorectal Resections
  6. 2025 Guidelines for Fluorescence Image-guided Surgery Using Indocyanine Green in Gastrointestinal Procedures - A SAGES Publication
  7. Indocyanine green near-infrared fluorescence bowel perfusion assessment to prevent anastomotic leakage in minimally invasive colorectal surgery (AVOID): a multicentre, randomised, controlled, phase 3 trial - ScienceDirect

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