Retraction: Metoprolol, N-Acetylcysteine, and Escitalopram Prevents Chronic Unpredictable Mild Stress-Induced Depression by Inhibition of Endoplasmic Reticulum Stress
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July 15, 2026
Retraction Notice: The Role of Metoprolol, N-Acetylcysteine, and Escitalopram
Background
The integrity of published research is crucial for advancing clinical knowledge and practice. Retractions serve as a mechanism to uphold scientific standards, especially in studies related to mental health treatments. This particular study aimed to explore novel pharmacological interventions for stress-induced depression.
Data Highlights
No numerical data is available due to the retraction of the original study.
Key Findings
- The original study was retracted due to concerns about image integrity in published figures.
- The authors did not provide raw data during the investigation.
- The retraction was approved by the Chief Editors of Frontiers in Psychiatry.
- Concerns were raised by users on PubPeer, prompting the investigation.
Clinical Implications
Healthcare professionals should be aware of the retraction and the implications for the validity of the findings regarding the pharmacological interventions studied.
Conclusion
The retraction of this study highlights the importance of data integrity in clinical research.
Related Resources & Content
- Frontiers Editorial Office, Frontiers in Psychiatry, 2026 -- Retraction: Metoprolol, N-Acetylcysteine, and Escitalopram Prevents Chronic Unpredictable Mild Stress-Induced Depression by Inhibition of Endoplasmic Reticulum Stress
- European Journal of Preventive Cardiology — Chronotropic incompetency during stress echocardiography: a new paradigm for mortality and cardiac event prediction?
- Basic Research in Cardiology — Coordination of Intracellular β1AR Signaling by Monoamine Oxidase A and Organic Cation Transporter 3 Modulates Cardiac Contractility
- Frontiers in Pain Research — Targeting endoplasmic reticulum stress: a novel therapeutic strategy for neuropathic pain
- Acta Neuropathologica — The Neuropathological Effects of Stress
- NICE guideline NG222
- Frontiers | Retraction: Metoprolol, N-Acetylcysteine, and Escitalopram Prevents Chronic Unpredictable Mild Stress-Induced Depression by Inhibition of Endoplasmic Reticulum Stress
- Efficacy of N-acetylcysteine for patients with depression: An updated systematic review and meta-analysis - ScienceDirect
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