Assessment of cardioprotective activity of a nitrate enriched food-based polyherbal formulation using experimental myocardial infarction in rats - Report - MDSpire

Assessment of cardioprotective activity of a nitrate enriched food-based polyherbal formulation using experimental myocardial infarction in rats

  • By

  • Sruthi Ramagiri

  • Hemraj Singh

  • Rajeev Taliyan

  • Yogendra Kumar Choudhary

  • Iwin Joseph Benny

  • July 10, 2026

  • 0 min

Share

Clinical Report: Evaluation of the Cardioprotective Effects of a Nitrate-Rich Herbal Food Formulation in a Rat Model of Myocardial Infarction

Overview

This study evaluates the cardioprotective effects of a nitrate-rich herbal formulation, Oxystorm, combined with turmeric extract in a rat model of myocardial infarction (MI). Results indicate that this formulation may reduce cardiac injury and inflammation while enhancing antioxidant defenses.

Background

Myocardial infarction (MI) is a leading cause of mortality worldwide, with significant implications for public health. The role of dietary interventions, particularly nitrate-rich herbal formulations, is gaining attention in managing cardiovascular diseases.

Data Highlights

BiomarkerEffect of Treatment
LDHDecreased
CK-MBDecreased
Troponin IDecreased
Interleukin-6Decreased
MalondialdehydeDecreased
GSHIncreased
SODIncreased

Key Findings

  • Oxystorm treatment significantly reduced levels of cardiac injury biomarkers (LDH, CK-MB, troponin I).
  • Inflammatory markers (interleukin-6) were decreased with Oxystorm treatment.
  • Oxystorm enhanced antioxidant defenses, indicated by increased levels of GSH and SOD.
  • The combination of Oxystorm and turmeric extract showed a synergistic effect in reducing infarct size.

Clinical Implications

Further research is needed to explore the underlying mechanisms of Oxystorm and its potential role in managing myocardial infarction.

Conclusion

The study demonstrates the potential of a nitrate-rich herbal formulation in providing cardioprotection in a rat model of myocardial infarction.

Related Resources & Content

  1. Basic Research in Cardiology, 2018 -- cGMP: Key Focus in Developing New Approaches to Activate the Cardioprotective PKG Pathway
  2. Basic Research in Cardiology, 2024 -- The Role of Insulin and Glycolysis in Cardioprotective Effects of Nicotinamide Riboside
  3. Basic Research in Cardiology, 2018 -- Evaluating the GTN Patch: A Novel and Efficient Strategy for Cardioprotection?
  4. Basic Research in Cardiology, 2022 -- Red Blood Cells from ST-Elevation Myocardial Infarction Patients Promote Cardioprotection via Purinergic P2Y13 Receptor and Nitric Oxide Pathways
  5. 2025 Guideline for Acute Coronary Syndromes - Professional Heart Daily | American Heart Association
  6. Plasma nitrate, dietary nitrate, blood pressure, and vascular health biomarkers: a GRADE-Assessed systematic review and dose-response meta-analysis of randomized controlled trials
  7. 2025 Guideline for Acute Coronary Syndromes - Professional Heart Daily | American Heart Association
  8. Plasma nitrate, dietary nitrate, blood pressure, and vascular health biomarkers: a GRADE-Assessed systematic review and dose-response meta-analysis of randomized controlled trials | Nutrition Journal | Springer Nature Link

Original Source(s)

Related Content