Clinical Report: Impact of Tegileridine Pretreatment on Cough Induced by Fentanyl

Overview

This study demonstrates that tegileridine pretreatment significantly reduces the incidence and severity of fentanyl-induced cough (FIC) during general anesthesia induction.

Background

Fentanyl-induced cough is a frequent complication during the induction of general anesthesia, with potential to elevate intracranial, intraocular, and intra-abdominal pressures. Effective management of FIC is clinically important to prevent serious complications. Tegileridine, a G-protein-biased μ-opioid receptor agonist, may offer a novel approach to reduce FIC.

Data Highlights

Key Findings

• Tegileridine pretreatment reduced FIC incidence from 28.7% to 11.1% (P = 0.001).
• The relative risk of FIC was reduced by 61.3% with tegileridine.
• Cough severity was significantly lower in the tegileridine group (P < 0.001).
• Hemodynamic changes (MAP and HR) did not differ significantly between groups.
• Immediate adverse events were uncommon in both groups.

Clinical Implications

Further studies are warranted to confirm the safety and efficacy of tegileridine in broader clinical settings.

Conclusion

Tegileridine 0.5 mg pretreatment effectively reduces FIC without causing hemodynamic instability.

Related Resources & Content

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