Luteinizing hormone supplementation and cumulative live birth rate in assisted reproductive technology cycles among women of advanced reproductive age - Report - MDSpire
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Luteinizing hormone supplementation and cumulative live birth rate in assisted reproductive technology cycles among women of advanced reproductive age
Clinical Report: Impact of Luteinizing Hormone Supplementation on Cumulative Live Birth Rates
Overview
This study evaluates the impact of luteinizing hormone (LH) supplementation on cumulative live birth rates (CLBR) in older women undergoing assisted reproductive technology (ART). Findings indicate that LH supplementation may enhance CLBR compared to follicle stimulating hormone (FSH) alone, although results should be interpreted cautiously.
Background
As more women delay childbearing, the population of older women seeking assisted reproductive technology (ART) is increasing. Advanced reproductive age is associated with decreased fertility, necessitating effective ovarian stimulation strategies. Understanding the role of luteinizing hormone (LH) supplementation in this context is crucial for optimizing ART outcomes.
Data Highlights
Group
Cumulative Live Birth Rate
Statistical Significance
rFSH
51.48%
-
rFSH + rLH
61.31%
P = 0.036
rFSH + HMG
52.99%
P = 0.102
Key Findings
Recombinant LH supplementation was associated with a higher CLBR compared to rFSH alone (61.31% vs. 51.48%, P = 0.036).
The rFSH + HMG group required significantly higher total gonadotropin doses and longer stimulation duration than the other groups (P < 0.001).
Fresh embryo transfer outcomes did not differ significantly between the groups.
In multivariable analyses, rFSH + rLH showed a higher probability of cumulative live birth compared to both rFSH alone and rFSH + HMG.
Baseline characteristics were well balanced across all treatment groups after propensity score matching.
Clinical Implications
Clinicians may consider LH supplementation during ART cycles for older women to potentially improve cumulative live birth rates. However, the decision should be individualized, taking into account the specific circumstances of each patient.
Conclusion
The findings suggest that LH supplementation may offer benefits in ART for older women, but further research is needed to confirm these results and establish clear guidelines for clinical practice.
