Predictors of Treatment Failure in Outpatient Management of Uncomplicated Skin and Soft Tissue Infections: Findings from a Prospective Multicenter Study in Türkiye - Report - MDSpire

Predictors of Treatment Failure in Outpatient Management of Uncomplicated Skin and Soft Tissue Infections: Findings from a Prospective Multicenter Study in Türkiye

  • By

  • Melike Nur Özçelik

  • Merve Sefa Sayar

  • Nurten Nur Aydın

  • Dilşah Başkol Elik

  • Özgür Günal

  • Pınar Yürük Atasoy

  • Ayşegül Tuna

  • Cihan Semet

  • Serpil Erol

  • Azize Yetişgen

  • Yakup Gezer

  • Muhammet Rıdvan Tayşi

  • Naciye Betül Baysal

  • Gülden Eser Karlıdağ

  • Muammer Çelik

  • Emsal Aydın

  • Yeşim Kürekçi

  • Yasemin Akkoyunlu

  • Özay Akyıldız

  • Ayşe Serra Özel

  • Oktay Yapıcı

  • Deniz Özer

  • Şafak Kaya

  • Tuba Damar Çakırca

  • Şafak Balın Özer

  • İsmail Necati Hakyemez

  • December 27, 2025

  • 0 min

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Predictors of Treatment Failure in Outpatient Management of SSTIs

Overview

Expand on the specific clinical and laboratory parameters that predict treatment failure.

Background

Skin and soft tissue infections (SSTIs) are prevalent and can lead to significant healthcare costs, particularly when hospitalization is required. Understanding the predictors of treatment failure in outpatient settings is crucial for optimizing management strategies and reducing unnecessary hospital admissions. This study aims to fill the knowledge gap regarding risk factors associated with outpatient treatment failure for uSSTIs.

Data Highlights

ParameterValue
Total Patients Enrolled599
Patients Hospitalized at Presentation169
Patients Requiring Hospitalization After Outpatient Treatment167

Key Findings

  • Outpatient treatment failure was defined as clinical deterioration requiring inpatient care.
  • 263 patients completed outpatient therapy successfully.
  • 169 patients were hospitalized at presentation, while 167 required hospitalization after initial outpatient treatment.
  • Clinical characteristics such as lesion size and location were collected and analyzed.
  • Laboratory parameters including WBC, CRP, and NLR were significant in predicting treatment outcomes.

Clinical Implications

Suggest specific monitoring strategies for clinicians to identify high-risk patients.

Conclusion

The study highlights the importance of identifying predictors of treatment failure in outpatient management of uSSTIs, which can lead to more effective treatment strategies and better resource utilization.

References

  1. Clinical and inflammatory predictors of outpatient treatment failure in uncomplicated skin and soft tissue infections: a prospective multicenter study from Türkiye, PMC, 2024 -- Clinical Features and Treatment Approaches
  2. I D S A G U I D E L I N E, IDSA, 2014 -- Practice Guidelines for the Diagnosis and Management of Skin and Soft Tissue Infections
  3. Managing Acute Uncomplicated Diverticulitis Without Antibiotics: Identifying Risk Factors for Treatment Failure
  4. Open Forum Infectious Diseases — Identifying Factors Associated with Treatment Failure in Outpatient Parenteral Antimicrobial Therapy at a Kentucky Academic Medical Center
  5. Open Forum Infectious Diseases — Clinical Features and Treatment Approaches for Non-Tuberculous Mycobacterial Skin and Soft Tissue Infections: A Retrospective Analysis
  6. Open Forum Infectious Diseases — Comparative Efficacy of Cefdinir and Cephalexin in Managing Uncomplicated Urinary Tract Infections
  7. I D S A G U I D E L I N E
  8. Efficacy and safety of first- and second-line antibiotics for cellulitis and erysipelas: a network meta-analysis of randomized controlled trials - PMC
  9. Clinical and inflammatory predictors of outpatient treatment failure in uncomplicated skin and soft tissue infections: a prospective multicenter study from Türkiye - PMC

Original Source(s)

Predictors of Treatment Failure in Outpatient Management of Uncomplicated Skin and Soft Tissue Infections: Findings from a Prospective Multicenter Study in Türkiye

  • by Melike Nur Özçelik, Merve Sefa Sayar, Nurten Nur Aydın, Dilşah Başkol Elik, Özgür Günal, Pınar Yürük Atasoy, Ayşegül Tuna, Cihan Semet, Serpil Erol, Azize Yetişgen, Yakup Gezer, Muhammet Rıdvan Tayşi, Naciye Betül Baysal, Gülden Eser Karlıdağ, Muammer Çelik, Emsal Aydın, Yeşim Kürekçi, Yasemin Akkoyunlu, Özay Akyıldız, Ayşe Serra Özel, Oktay Yapıcı, Deniz Özer, Şafak Kaya, Tuba Damar Çakırca, Şafak Balın Özer, İsmail Necati Hakyemez

  • December 27, 2025

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