Clinical Report: Prognostic Nomogram for Oral Squamous Cell Carcinoma

Overview

This study developed a prognostic nomogram for oral squamous cell carcinoma (OSCC) that integrates traditional clinical parameters with the fibrinogen-to-neutrophil-lymphocyte ratio (F-NLR) and the hemoglobin-albumin-globulin ratio (HAGR).

Background

Oral squamous cell carcinoma (OSCC) is the most common malignancy of the head and neck, characterized by aggressive behavior and poor long-term survival rates. Traditional prognostic evaluations primarily rely on the TNM staging system, which does not adequately account for biological variability among patients. This study aims to enhance prognostic accuracy by incorporating systemic inflammatory and nutritional markers into a novel nomogram.

Data Highlights

Key Findings

• Age, history of precancerous lesions, N classification, postoperative adjuvant therapy, F-NLR, and HAGR scores were identified as independent prognostic factors.
• The nomogram showed a C-index of 0.73.
• Calibration plots indicated high consistency between predicted and actual survival probabilities.
• The AUC values for predicting 1-, 3-, and 5-year cancer-specific survival were 0.798, 0.754, and 0.836, respectively.
• Internal validation suggests potential utility for the nomogram in risk stratification.

Clinical Implications

The integration of F-NLR and HAGR scores into a prognostic nomogram may provide a more individualized approach to risk stratification in OSCC patients. This model could assist clinicians in making more informed decisions regarding treatment strategies.

Conclusion

The proposed nomogram demonstrates predictive accuracy for OSCC survival outcomes, warranting further external validation in multi-center studies.

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8. Hematological parameters as predictors of oral cancer prognosis: a systematic review and meta-analysis | Journal of Cancer Research and Clinical Oncology | Springer Nature Link
9. Prognostic value of platelet-to-lymphocyte ratio in patients with oral squamous cell carcinoma: a systematic review and meta-analysis | BMC Oral Health | Springer Nature Link
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