Prehabilitation in cancer care: an evolving field - Report - MDSpire

Prehabilitation in cancer care: an evolving field

  • By

  • Christopher Gaffney

  • Jessica Gorzelitz

  • Jack Reeves

  • Daniel Steffens

  • June 26, 2026

  • 0 min

Share

Clinical Report: Optimizing Patient Resilience: The Growing Role of Prehabilitation in Cancer Treatment

Overview

Prehabilitation is a systematic approach aimed at optimizing patients' physical, nutritional, and psychological conditions before cancer treatment. Evidence suggests that prehabilitation may reduce complications and improve recovery.

Background

Cancer treatments impose significant physiological and psychological stress on patients, making them vulnerable during critical periods. Prehabilitation has emerged as a strategy to enhance patients' resilience by addressing modifiable risk factors such as deconditioning and malnutrition. An international survey confirmed that prehabilitation is offered to all cancer patients in only 21% of hospitals.

Data Highlights

No specific numerical data provided in the source material.

Key Findings

  • Preoperative functional capacity is a strong predictor of postoperative outcomes across cancer types.
  • A 2022 umbrella review confirmed that prehabilitation may reduce complications and improve recovery.
  • The PREHAB trial showed that a four-week supervised multimodal program reduced severe postoperative complications.
  • The GISSG + 2201 trial demonstrated that two weeks of supervised home-based prehabilitation significantly reduced overall complication rates in frail patients.
  • The PREPARE trial found no significant improvement in disability scores or complication rates.
  • An international Delphi study identified key research priorities for prehabilitation.

Clinical Implications

Healthcare providers should consider implementing prehabilitation programs for high-risk patients.

Conclusion

Further research is needed to refine the implementation and effectiveness of prehabilitation.

Related Resources & Content

  1. Author(s)/Org, Source, Year -- Title
  2. Insights from Cancer Survivors on the Necessary Support and Resources for an Effective Prehabilitation Program, Springer, 2023
  3. Prehabilitation Program May Benefit Patients Undergoing CRC Surgery, conexiant, 2023
  4. Evaluating the Effects of Prehabilitation on Surgical Outcomes in Oesophageal Cancer, Journal of Gastrointestinal Surgery, 2020
  5. Macmillan Cancer Support, Clinical and Implementation Guidelines, 2025
  6. ERAS Elements - Homepage | ERAS Society
  7. Guideline Topic Priorities - ASCO
  8. Relative efficacy of prehabilitation interventions and their components, PMC, 2025
  9. Multimodal prehabilitation is an effective strategy to reduce postoperative complications, Frontiers in Medicine, 2025
  10. Immune Modulation by Personalized vs. Standard Prehabilitation Before Major Surgery, PubMed, 2023
  11. https://www.macmillan.org.uk/dfsmedia/1a6f23537f7f4519bb0cf14c45b2a629/22869-10061/prehabilitation-for-people-with-cancer-clinical-and-implementation-guidelines
  12. ERAS Elements - Homepage | ERAS Society
  13. Guideline Topic Priorities - ASCO
  14. Relative efficacy of prehabilitation interventions and their components: systematic review with network and component network meta-analyses of randomised controlled trials - PMC
  15. Multimodal prehabilitation is an effective strategy to reduce postoperative complications and improve physical function and anxiety in patients with colorectal cancer undergoing elective surgery: a systematic review and network meta-analysis
  16. Immune Modulation by Personalized vs. Standard Prehabilitation Before Major Surgery: A Randomized Controlled Trial
  17. Integrating Telerehabilitation into the Prehabilitation and Rehabilitation Pathway in Colorectal Cancer: A Protocol for a Randomized Controlled Trial | medRxiv

Original Source(s)

Related Content