Efficacy and safety of linaclotide plus polyethylene glycol for bowel preparation before colonoscopy in elderly Chinese patients: a systematic review and meta-analysis - Report - MDSpire
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Efficacy and safety of linaclotide plus polyethylene glycol for bowel preparation before colonoscopy in elderly Chinese patients: a systematic review and meta-analysis
Effectiveness and Safety of Combining Linaclotide with Polyethylene Glycol for Bowel Preparation Prior to Colonoscopy in Older Chinese Adults
Overview
This systematic review and meta-analysis evaluated the effectiveness of linaclotide combined with polyethylene glycol (PEG) for bowel preparation in elderly Chinese adults. This combination improves bowel cleansing quality and reduces procedure time.
Background
Colonoscopy is a critical procedure for colorectal cancer screening and diagnosis, particularly in elderly patients who often experience inadequate bowel preparation. Inadequate preparation can lead to missed lesions and prolonged procedure times, making effective bowel cleansing essential. Linaclotide, a guanylate cyclase C receptor agonist, may enhance bowel preparation by improving intestinal secretion and transit, potentially addressing the challenges faced by older adults.
Data Highlights
Outcome
Result
95% CI
p-value
Total bowel cleansing quality
MD = 0.93
(0.66–1.20)
< 0.00001
Vomiting risk
RR = 0.60
(0.41–0.86)
0.006
Abdominal pain risk
RR = 0.57
(0.34–0.94)
0.03
Abdominal distension risk
RR = 0.61
(0.38–0.98)
0.04
Nausea risk
RR = 0.59
(0.38–0.92)
0.02
Total procedure time
MD = −2.35 min
(−3.11 to −1.60)
< 0.00001
Polyp detection rate
RR = 1.25
(1.01–1.55)
0.04
Key Findings
Linaclotide plus PEG improved total bowel cleansing quality compared to PEG alone.
Lin + PEG reduced the risk of vomiting, abdominal pain, abdominal distension, and nausea.
No significant difference in total adverse events was observed between the two groups.
Lin + PEG decreased total procedure time by an average of 2.35 minutes.
The polyp detection rate was higher in the Lin + PEG group.
Clinical Implications
The combination of linaclotide and PEG may enhance bowel preparation quality in elderly patients undergoing colonoscopy.
Conclusion
Linaclotide combined with PEG improves cleansing quality and reduces procedure time.
