Clinical Report: Efficacy of Ginkgo biloba Extract in Managing Dizziness Symptoms
Overview
This systematic review and meta-analysis evaluated the efficacy and safety of Ginkgo biloba extract for managing dizziness linked to central neurological disorders.
Background
Dizziness associated with central neurological disorders is a common and debilitating symptom, affecting a significant portion of the adult population, especially the elderly. This condition is often persistent and linked to serious neurological diseases, leading to increased morbidity and healthcare utilization. Current treatment options are limited.
Data Highlights
Outcome
Effect Size
Confidence Interval
p-value
Dizziness severity (11-point box scale)
MD −0.76
95% CI −1.35 to −0.18
0.01
Dizziness severity (VAS)
SMD −0.38
95% CI −0.58 to −0.19
0.0001
ADLs (Alzheimer’s Disease Activities of Daily Living)
MD −0.17
95% CI −0.22 to −0.13
N/A
Dementia Quality of Life – Proxy
MD 2.00
95% CI 0.85 to 3.15
N/A
Angina pectoris risk
OR 0.51
95% CI 0.31 to 0.85
N/A
Tinnitus risk
OR 0.37
95% CI 0.22 to 0.63
N/A
Key Findings
Nine RCTs with 2,394 participants were included in the analysis.
71.6% of participants were from dementia populations.
Ginkgo biloba significantly reduced dizziness severity on both the 11-point box scale and VAS.
Moderate-certainty evidence indicated improvements in functional outcomes and quality of life.
The intervention had a favorable safety profile with lower risks of angina pectoris and tinnitus.
Findings should be interpreted with caution due to clinical and statistical heterogeneity.
Clinical Implications
Clinicians should be aware of the safety profile of Ginkgo biloba extract when discussing treatment options with patients.
Conclusion
Further well-designed RCTs are needed to confirm these findings in clearly defined populations.
