Efficacy and safety of full-endoscopic sacroiliac joint denervation for the treatment of chronic low back pain: a systematic review - Report - MDSpire

Efficacy and safety of full-endoscopic sacroiliac joint denervation for the treatment of chronic low back pain: a systematic review

  • By

  • Dia R. Halalmeh

  • Yusuf-Zain Ansari

  • Arwa Jader

  • Rahul Kumar

  • Amy Herrera

  • Saqib Hasan

  • February 25, 2026

  • 0 min

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Clinical Report: Full-Endoscopic Sacroiliac Joint Denervation for Chronic Low Back Pain

Overview

This systematic review evaluates the safety and efficacy of full-endoscopic sacroiliac joint denervation (FE-SJD) in managing chronic low back pain (CLBP). The analysis highlights FE-SJD as a minimally invasive technique offering promising pain relief and functional improvement with a favorable safety profile.

Background

Chronic low back pain (CLBP) is a prevalent condition affecting a significant portion of the global population and imposing substantial healthcare costs. Sacroiliac joint (SIJ) dysfunction accounts for 15% to 30% of CLBP cases. Traditional surgical treatments, such as SIJ arthrodesis, have evolved over the past century but often involve long recovery and complications. Minimally invasive approaches, including denervation techniques like radiofrequency ablation, have emerged to improve outcomes. FE-SJD is a novel minimally invasive method targeting nerve roots with greater precision, though long-term data remain limited.

Data Highlights

The systematic review included multiple studies assessing FE-SJD outcomes. Data extracted encompassed patient demographics, surgical details, pre- and postoperative pain and disability scores (VAS and ODI), operative time, blood loss, and complications. Meta-analyses were performed to evaluate changes in VAS and ODI scores, with statistical models selected based on heterogeneity (I2 statistic). Risk of bias was assessed using the ROBINS-I tool.

Key Findings

  • FE-SJD demonstrated significant reductions in Visual Analog Scale (VAS) pain scores postoperatively, indicating effective pain relief.
  • Oswestry Disability Index (ODI) scores improved following FE-SJD, reflecting enhanced functional outcomes.
  • The procedure showed a low rate of intraoperative and postoperative complications, supporting its safety.
  • Operative times and estimated blood loss were minimal, consistent with the minimally invasive nature of FE-SJD.
  • FE-SJD offers a precise targeting of nerve branches responsible for SIJ-related CLBP compared to traditional denervation methods.
  • Current evidence is limited by the number and quality of studies, highlighting the need for further high-quality research.

Clinical Implications

FE-SJD represents a promising minimally invasive surgical option for patients with SIJ-mediated CLBP, providing effective pain relief and functional improvement with a favorable safety profile. Clinicians should consider FE-SJD as an alternative to more invasive fusion procedures, especially in patients refractory to conservative management. However, careful patient selection and further longitudinal studies are warranted to establish long-term outcomes.

Conclusion

Full-endoscopic sacroiliac joint denervation is an effective and safe technique for managing chronic low back pain related to SIJ dysfunction. While current data are encouraging, additional high-quality studies are necessary to confirm its long-term efficacy and safety.

References

  1. Systematic Review Authors/2024 -- Assessment of the effectiveness and safety of full-endoscopic sacroiliac joint denervation in managing chronic low back pain

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