Prevalence and Initial Predictors of Treatment Discontinuation in DRCRnet Research Studies
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By
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Klyve N. Otinkorang
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Gui-shuang Ying
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September 11, 2026
Prevalence and Initial Predictors of Treatment Discontinuation in DRCRnet Research Studies
Overview
This study investigates the prevalence and predictors of treatment discontinuation in diabetic retinopathy (DR) clinical trials.
Background
Diabetic retinopathy is a leading cause of preventable blindness, particularly affecting racial and ethnic minority populations. Discontinuation of treatment in clinical studies can lead to biased results and hinder the generalizability of findings.
Data Highlights
No specific numerical data was provided in the source material.
Key Findings
- Discontinuation rates in DR studies can significantly affect statistical power and treatment effect estimates.
- Demographic and clinical variables may predict participant discontinuation in DR clinical trials.
- Racial and ethnic disparities contribute to differences in treatment adherence and follow-up.
- Inadequate retention in studies accelerates vision loss and disease progression.
- Structural and social determinants of health influence outcomes in diabetic retinopathy.
Clinical Implications
Identifying predictors of treatment discontinuation can inform study design and strategies to enhance participant retention.
Conclusion
Understanding treatment discontinuation in diabetic retinopathy studies is important for participant retention.
Related Resources & Content
- American Diabetes Association, Diabetes Care, 2026 -- Retinopathy, Neuropathy, and Foot Care: Standards of Care in Diabetes—2026
- JAMA Network, 2019 -- Effect of Initial Management With Aflibercept vs Laser Photocoagulation vs Observation on Vision Loss Among Patients With Diabetic Macular Edema Involving the Center of the Macula and Good Visual Acuity: A Randomized Clinical Trial
- JAMA Network Open, 2024 -- Loss to Follow-Up in Patients With Proliferative Diabetic Retinopathy or Diabetic Macular Edema
- Open Forum Infectious Diseases — Withdrawal from Long-acting Injectable Cabotegravir-Rilpivirine in a Large Clinical Population
- Open Forum Infectious Diseases — Predictors of Early Termination of Preventive Therapy in Children Exposed to Multidrug-Resistant Tuberculosis in Household Settings
- Open Forum Infectious Diseases — Long-Term Outcomes Following the Transition to Dolutegravir Amidst Significant Civil Unrest in Haiti: A Three-Year Analysis
- Open Forum Infectious Diseases — Factors Influencing Clinical Outcomes in Individuals with HIV and Tuberculosis Symptoms Following Prompt Treatment Initiation in Haiti
- 12. Retinopathy, Neuropathy, and Foot Care: Standards of Care in Diabetes—2026 | Diabetes Care | American Diabetes Association
- Effect of Initial Management With Aflibercept vs Laser Photocoagulation vs Observation on Vision Loss Among Patients With Diabetic Macular Edema Involving the Center of the Macula and Good Visual Acuity: A Randomized Clinical Trial | Ophthalmology | JAMA | JAMA Network
- Loss to Follow-Up in Patients With Proliferative Diabetic Retinopathy or Diabetic Macular Edema | Equity, Diversity, and Inclusion | JAMA Network Open | JAMA Network
Based on findings from:
Incidence and baseline predictors of discontinuation in DRCRnet studies
Klyve N. Otinkorang, Gui-shuang Ying. Eye, 2026.
https://www.nature.com/articles/s41433-026-04853-y
This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.
