Management of ocular surface disease involving inflammation and persistent epithelial defects utilising various treatment modalities in the UK National Health Service (NHS) - Report - MDSpire

Management of ocular surface disease involving inflammation and persistent epithelial defects utilising various treatment modalities in the UK National Health Service (NHS)

  • By

  • Sundas Ejaz Maqsood

  • John William Posnett

  • Mohamed Elalfy

  • June 4, 2026

  • 0 min

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Clinical Report: Approaches to Treating Inflammatory Ocular Surface Disease

Overview

This report evaluates the management of persistent corneal epithelial defects (PED) within the UK NHS, highlighting clinical outcomes, treatment burden, and economic costs associated with these cases.

Background

Persistent corneal epithelial defects (PED) can lead to complications, including vision loss. Management requires understanding its diverse aetiology and necessitates a stepwise treatment approach. There is limited data on treatment burden and costs associated with PED within the NHS.

Data Highlights

No numerical data available in the source material.

Key Findings

['PED is defined by failure of corneal re-epithelialisation beyond 10–14 days despite appropriate treatment.', 'Management of PED requires a multifactorial approach addressing both the underlying cause and promoting epithelial healing.', 'Common treatment modalities include intensive lubrication, bandage contact lenses, punctal plugs, and surgical options like amniotic membrane transplantation.', 'Chronic PEDs generate a high cumulative burden due to prolonged healing times and frequent monitoring.', 'There is a lack of unified coding for PED in national data systems, complicating evaluation of service impact.']

Clinical Implications

Healthcare professionals should be aware of the multifactorial nature of PED management.

Conclusion

The management of persistent corneal epithelial defects presents clinical and economic challenges within the NHS.

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  3. PMC, 2025 -- Efficacy of Different Concentrations of Autologous Serum Eye Drops in the Treatment of Ocular Surface Diseases: A Systematic Review and Meta-Analysis
  4. Presbyopia Physician — Ocular Surface and Lid Margin Optimization Prior to Refractive Cataract Surgery
  5. Optometric Management — CLINICAL: Dry Eye Recommendations
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  8. Ocular Surface and Lid Margin Optimization Prior to Refractive Cataract Surgery
  9. CLINICAL: Dry Eye Recommendations
  10. CLINICAL: Dry Eye
  11. Overview | Ciclosporin for treating dry eye disease that has not improved despite treatment with artificial tears | Guidance | NICE
  12. Topical Recombinant Human Nerve Growth Factor (Cenegermin) for Neurotrophic Keratopathy: A Multicenter Randomized Vehicle-Controlled Pivotal Trial - ScienceDirect
  13. Efficacy of Different Concentrations of Autologous Serum Eye Drops in the Treatment of Ocular Surface Diseases: A Systematic Review and Meta-Analysis - PMC

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