Metabolic Risk Factors Are Associated With Weight Status Change Over Four Years in Children Aged 4–6 Years With Obesity - Report - MDSpire
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Association of Metabolic Risk Factors with Changes in Weight Status Over Four Years Among Obese Children Aged 4 to 6 Years

  • By

  • Markus Brissman

  • Anna Ek

  • Stella Wennborg

  • Karin Nordin

  • Karin Eli

  • Annika Janson

  • Paulina Nowicka

  • June 5, 2026

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Clinical Report: Association of Metabolic Risk Factors with Changes in Weight Status

Overview

This study evaluates the long-term metabolic health of obese children aged 4-6 years and examines the relationship between changes in weight status and metabolic risk markers. Data from the More and Less study are presented.

Background

Childhood obesity is linked to significant long-term health risks, including type 2 diabetes and cardiovascular disease. Understanding metabolic risk factors in preschool-aged children is crucial. This study addresses a gap in the literature regarding metabolic profiles of children under six years of age.

Data Highlights

No specific numerical data or trial results are provided in the source material.

Key Findings

  • Obesity in early childhood is associated with impaired metabolic health.
  • Low-grade inflammation can be present in children with obesity as young as two years old.
  • Only two obesity treatment programs for preschool-aged children have been evaluated in randomized controlled trials.
  • The More and Less program showed improvements in children's weight status.

Clinical Implications

Healthcare professionals should monitor metabolic risk factors in obese children aged 4-6 years, as early intervention may lead to improved health outcomes. The findings support the need for effective obesity treatment programs tailored for this age group.

Conclusion

The study presents findings on metabolic health in preschool-aged children with obesity.

Related Resources & Content

  1. Author(s)/Org, Source, Year -- Title
  2. The Journal of Clinical Endocrinology & Metabolism, 2023 -- Links Between Growth Rates of Body Mass Index, Body Composition, and Cardiometabolic Risk Factors in Preschoolers in China
  3. The Journal of Clinical Endocrinology & Metabolism, 2023 -- Links Between Plasma and Fecal Metabolites and Body Mass Index Along with Body Fat Distribution in Pediatric Populations
  4. BMJ Paediatrics Open, 2023 -- Metabolically obese normal weight phenotype in children and adolescents aged 3 to 18 years: a systematic review
  5. Executive Summary: Clinical Practice Guideline for the Evaluation and Treatment of Children and Adolescents With Obesity | Pediatrics | American Academy of Pediatrics, 2023
  6. Children and Adolescents: Standards of Care in Diabetes—2026 | Diabetes Care | American Diabetes Association, 2026
  7. Executive Summary: Clinical Practice Guideline for the Evaluation and Treatment of Children and Adolescents With Obesity | Pediatrics | American Academy of Pediatrics
  8. 14. Children and Adolescents: Standards of Care in Diabetes—2026 | Diabetes Care | American Diabetes Association

Original Source(s)

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