Hepatitis C Testing at the Point of Care in Indigenous Communities - Report - MDSpire

Hepatitis C Testing at the Point of Care in Indigenous Communities

  • By

  • Jorge Mera

  • Andrea Blair

  • Kendra Lewis

  • Savana Christy

  • Molly Feder

  • Ashley Comiford

  • April 15, 2026

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Clinical Report: Hepatitis C Testing at the Point of Care in Indigenous Communities

Overview

Revise to clarify the timeline of the Cherokee Nation's program and data collection.

Background

Hepatitis C virus (HCV) infection significantly impacts American Indian and Alaska Native populations, with the highest incidence rates reported in 2023. Traditional testing methods often lead to delays in diagnosis and treatment, exacerbating health disparities. The introduction of POC testing aims to address these gaps by facilitating immediate diagnosis and treatment initiation.

Data Highlights

No numerical data available in the provided source material.

Key Findings

  • HCV incidence among American Indian and Alaska Native people is 3.5 cases per 100,000, the highest among all racial groups.
  • 28% to 93% of individuals with a positive HCV antibody test do not receive confirmatory RNA testing.
  • POC HCV RNA testing has been shown to improve diagnosis and treatment uptake in community settings.
  • The Cherokee Nation implemented POC HCV RNA testing in October 2024, becoming the first US tribal health system to do so.
  • Participants in the Cherokee Nation program received incentives to promote engagement in testing and treatment.

Clinical Implications

The adoption of POC HCV RNA testing can significantly enhance the diagnostic process and treatment initiation for high-risk populations. Healthcare providers should consider integrating POC testing into their practices to reduce barriers to care and improve health outcomes in Indigenous communities.

Conclusion

Reiterate the importance of ongoing evaluation and support, linking to specific challenges.

Related Resources & Content

  1. CDC, 2023 — 2023 Viral Hepatitis National Profile
  2. Open Forum Infectious Diseases, 2023 — Economic Evaluation of Various Hepatitis C Diagnosis and Treatment Strategies
  3. The Journal of Infectious Diseases, 2023 — Rapid Hepatitis C Virus RNA Testing at the Point of Care Achieves 15-Minute Results
  4. The Journal of Infectious Diseases, 2023 — Creation of a Quick Automated Point-of-Care Test for Hepatitis C Viral RNA
  5. Open Forum Infectious Diseases, 2023 — Streamlined Hepatitis C Virus Testing and Treatment Protocol for Homeless Individuals Who Inject Drugs
  6. Point-of-Care Hepatitis C Testing in a Tribal Setting
  7. Updated Operational Guidance for Implementing CDC’s Recommendations on Testing for Hepatitis C Virus Infection
  8. 2023 Viral Hepatitis National Profile | 2023 Hepatitis Surveillance | CDC

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