Clinical Report: Enhancing Endogenous GLP-1 Secretion and Satiety Through Dietary Fibers
Overview
This scoping review evaluates the effects of dietary fibers on endogenous GLP-1 secretion and satiety. Dextrins emerged as a promising fiber type, showing positive effects on both outcomes.
Background
Dietary fibers can stimulate GLP-1 secretion, which is crucial for appetite regulation and weight management. Understanding the relationship between fiber types and GLP-1 responses is essential for developing effective dietary recommendations.
Data Highlights
Study Type
Number of Studies
Participants
Median Sample Size
Acute Interventions
52
1,085
19
Key Findings
49 publications comprising 52 studies were included in the review.
71% of studies were acute interventions conducted in Western populations.
Dextrins showed effects on both GLP-1 and satiety with 4 and 5 positive studies, respectively.
Other fibers like β-glucans and mannans had more uniform effects but did not consistently affect both GLP-1 and satiety.
Studies reporting increased GLP-1 showed a non-significant tendency to also report increased satiety (OR = 2.95).
Clinical Implications
Further research is necessary to establish long-term effects and practical applications in clinical settings.
Conclusion
Further studies are needed to strengthen the evidence base.
In a pooled analysis of two randomized crossover trials, reducing nightly sleep by about 1.5 hours for 6 weeks was associated with modest increases in body weight and waist circumference without measurable changes in body composition.
