Thyroid Feedback Quantile Index as a Predictor of 90-Day Mortality in HF

Overview

The Thyroid Feedback Quantile-Based Index (TFQI) is associated with increased risk of 90-day all-cause mortality in hospitalized heart failure patients. A TFQI threshold of 0.10 effectively stratifies high-risk patients.

Background

Heart failure (HF) is a prevalent condition with significant morbidity and mortality, affecting approximately 6.2 million adults in the U.S. High rates of hospital readmissions and mortality post-discharge highlight the need for effective risk stratification tools. The TFQI, derived from TSH and FT4 levels, offers a novel approach to assess thyroid hormone sensitivity.

Data Highlights

Key Findings

• A TFQI threshold of 0.10 stratifies high-risk heart failure patients.
• Patients with TFQI > 0.10 have a significantly worse survival rate (Log-rank P = 0.004).
• Univariate and multivariate Cox regression analyses support the predictive value of TFQI.
• RCS analysis indicates a linear dose-response relationship for TFQI.

Clinical Implications

The identification of TFQI as a predictive marker for mortality and readmission in heart failure patients may guide clinicians in risk stratification and management decisions. Further research is needed to validate these findings in larger, multicenter studies.

Conclusion

TFQI is associated with increased risk of adverse outcomes in hospitalized heart failure patients.

Related Resources & Content

1. The Journal of Clinical Endocrinology & Metabolism, 2022 -- Assessing Cardiovascular Risk in Euthyroid Koreans: The Impact of the Parametric Thyroid Feedback Quantile Index
2. The Journal of Clinical Endocrinology & Metabolism, 2022 -- Subclinical Hypothyroidism as a Distinct Predictor of Cardiovascular Outcomes in Patients with Left Ventricular Thrombus
3. The Journal of Clinical Endocrinology & Metabolism, 2022 -- Thyroid Activity and Overall Mortality in Relation to Multimorbidity: Findings from Two Population-Based Studies
4. 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure | JACC
5. Prognostic Impact of Thyroid Function in Patients With Incident Heart Failure: A Nationwide Study - PubMed
6. The Journal of Clinical Endocrinology & Metabolism — Thyroid Hormone Levels and Their Impact on Chronic Kidney Disease Outcomes
7. 2022 AHA/ACC/HFSA Heart Failure Guideline
8. Prognostic Impact of Thyroid Function in Heart Failure
9. Thyroid hormone sensitivity and diabetes onset: a longitudinal cross-lagged cohort - PMC