Clinical Report: Investigation of NHR and UHR Ratios in Early Pregnancy

Overview

This study investigates the relationship between the neutrophil to HDL cholesterol ratio (NHR) and uric acid to HDL cholesterol ratio (UHR) in early pregnancy as predictors for gestational diabetes mellitus (GDM). Elevated levels of NHR and UHR were found to be independent risk factors for GDM development.

Background

Gestational diabetes mellitus (GDM) is associated with significant adverse pregnancy outcomes and long-term health risks for mothers and infants. Identifying biomarkers for early prediction of GDM can facilitate timely interventions, potentially improving maternal and neonatal health. Current diagnostic practices primarily rely on glucose tolerance tests conducted later in pregnancy, highlighting the need for early predictive markers.

Data Highlights

Key Findings

• Patients in the GDM group exhibited significantly elevated NHR and UHR levels compared to the non-GDM group (P < 0.001).
• Glucose levels during the OGTT increased with higher NHR and UHR quartiles (P < 0.001).
• Serum NHR and UHR levels were positively correlated with GDM (P < 0.001).
• NHR and UHR were identified as independent risk factors for GDM development (P < 0.001).
• ROC analysis indicated that NHR and UHR could serve as predictive markers for GDM after 24 weeks of gestation.

Clinical Implications

The findings suggest that NHR and UHR could be utilized as early biomarkers for identifying women at risk for GDM. Incorporating these ratios into routine early pregnancy assessments may enhance risk stratification and facilitate early interventions.

Conclusion

Elevated NHR and UHR levels in early pregnancy are significant predictors of GDM, providing valuable insights for early clinical prevention and management strategies.

Related Resources & Content

1. American Diabetes Association, Diabetes Care, 2025 -- Diagnosis and Classification of Diabetes: Standards of Care in Diabetes—2026
2. Scientific Reports, 2025 -- The predictive value of neutrophil to high-density lipoprotein cholesterol ratio in early pregnancy for gestational diabetes based on nomogram
3. The Journal of Clinical Endocrinology & Metabolism, 2025 -- Variability in Gestational Diabetes and Its Association with Negative Pregnancy Outcomes: Findings from a Cohort Analysis
4. The Journal of Clinical Endocrinology & Metabolism, 2025 -- Comparative Analysis of Early Intervention and Monitoring in Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
5. The Journal of Clinical Endocrinology & Metabolism, 2025 -- Dietary Patterns Linked to Insulin and Inflammation May Better Predict Gestational Diabetes Mellitus Risk
6. Archives of Gynecology and Obstetrics — Advanced fetal cardiac monitoring in gestational diabetes mellitus: HbA1c remains the relevant predictor of perinatal outcome under optimal metabolic control
7. 2. Diagnosis and Classification of Diabetes: Standards of Care in Diabetes—2026 | Diabetes Care | American Diabetes Association
8. The predictive value of neutrophil to high-density lipoprotein cholesterol ratio in early pregnancy for gestational diabetes based on nomogram | Scientific Reports