Assessment of hemoglobin-to-red cell distribution width ratio to predict all-cause mortality in patients with sepsis: a retrospective cohort study from the MIMIC-IV database - Report - MDSpire
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Assessment of hemoglobin-to-red cell distribution width ratio to predict all-cause mortality in patients with sepsis: a retrospective cohort study from the MIMIC-IV database
Clinical Report: Evaluation of the Hemoglobin-to-Red Cell Distribution Width Ratio as a Predictor of All-Cause Mortality in Sepsis Patients
Overview
This study investigates the Hemoglobin-to-Red Cell Distribution Width Ratio (HRR) as a prognostic indicator for 28-day mortality in sepsis patients using data from the MIMIC-IV database. Findings indicate that a higher HRR correlates with lower mortality rates.
Background
Sepsis is a critical condition with high mortality rates, necessitating effective prognostic tools for better patient management. The HRR may reflect both inflammatory and nutritional status, which are crucial in sepsis prognosis.
Data Highlights
Group
28-Day Mortality Rate
High-score
20.23%
Low-score
25.72%
Key Findings
The study included 28,812 sepsis patients, with a 28-day mortality rate of 19.77%.
Post-propensity score matching, the high-score HRR group had a significantly lower mortality rate compared to the low-score group (20.23% vs. 25.72%, P < 0.05).
Cox proportional hazards regression indicated that the high-score group had a reduced risk of 28-day mortality (HR, 0.73; 95% CI, 0.68–0.79).
Threshold analysis identified 0.78 as the inflection point for HRR, below which each unit increase in HRR correlated with a 26% decrease in mortality risk (HR, 0.26; 95% CI, 0.19–0.38).
Integrating HRR with disease severity scores enhances predictive accuracy for 28-day mortality.
Clinical Implications
The HRR may aid clinicians in risk stratification for sepsis.
Conclusion
The HRR demonstrates a significant negative correlation with 28-day mortality in sepsis patients.
