Clinical Report: Correction on Brain States and Working Memory in Schizophrenia

Overview

This correction addresses errors in the original article regarding brain state dynamics and working memory in schizophrenia patients and their unaffected siblings. Key revisions clarify statistical findings related to low-demand states and high-demand states during cognitive tasks.

Background

Schizophrenia is a chronic mental disorder affecting approximately 1% of the global population, characterized by cognitive impairments that significantly impact daily functioning. Understanding the dynamics of brain states during working memory tasks is crucial for identifying cognitive deficits and potential interventions. This correction highlights the importance of accurate reporting in research to inform clinical practice and future studies.

Data Highlights

No new numerical data presented in this correction.

Key Findings

• Patients with schizophrenia showed reduced occupancy and lifetime of the high-demand state during the ‘2-back’ load.
• Increased occupancy and lifetime of the fixation state were observed during both task periods in patients compared to controls and siblings.
• The reduction in the low-demand state during the ‘0-back’ load did not survive FDR correction, indicating no significant group difference.
• Errors in the original article included misalignment in Table 2 and misinterpretation of statistical significance in the discussion.
• Family history is a strong predictor of schizophrenia risk, emphasizing the need for studies on unaffected relatives.

Clinical Implications

Clinicians should be aware of the cognitive deficits associated with schizophrenia, particularly in working memory tasks. Accurate interpretation of research findings is essential for developing effective cognitive interventions and understanding the familial aspects of the disorder.

Conclusion

This correction underscores the necessity for precise reporting in clinical research, which is vital for advancing understanding and treatment of cognitive impairments in schizophrenia.

References

1. BMC Medicine, 2025 -- Dynamics of Brain States and Working Memory in Schizophrenia Patients and Their Unaffected Siblings
2. BMC Psychiatry (Springer) — Disruption of Circadian Rhythms in Schizophrenia and Genetic Predisposition: A Comparative Analysis
3. BMC Psychiatry (Springer) — Moderating role of familial relationships in the efficacy of rTMS intervention on cognitive function in patients with schizophrenia
4. BMC Psychiatry (Springer) — Dynamic functional connectivity and coupling analysis of triple networks and white matter functional networks in first-episode schizophrenia patients: mechanisms revealed by follow-up studies
5. BMC Psychiatry (Springer) — Working memory and its neural characteristics in male schizophrenia patients with or without a history of violent behavior: an exploratory fNIRS study
6. Psychosocial Management of First-Episode Psychosis and Schizophrenia: Synopsis of the US Department of Veterans Affairs and US Department of Defense Clinical Practice Guidelines
7. Brain state dynamics and working memory in patients with schizophrenia and unaffected siblings | BMC Medicine | Full Text
8. Psychosocial Management of First-Episode Psychosis and Schizophrenia: Synopsis of the US Department of Veterans Affairs and US Department of Defense Clinical Practice Guidelines