Perceived Risk of Fentanyl Use Among US Adolescents - Report - MDSpire

Perceived Risk of Fentanyl Use Among US Adolescents

  • By

  • Richard Miech

  • Megan E. Patrick

  • Justin Jager

  • Joy Bohyun Jang

  • July 7, 2026

  • 0 min

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Adolescents' Perception of Fentanyl Usage Risks in the United States

Overview

This study presents the first nationally representative estimates of perceived risk of fentanyl use among US adolescents in 8th, 10th, and 12th grades.

Background

Fentanyl is a significant contributor to adolescent overdose deaths, accounting for at least 75% of such fatalities. The rate of overdose mortality among adolescents has doubled from 2019 to 2020, making drug overdoses the third leading cause of death in this demographic.

Data Highlights

The study utilized data from the 2025 Monitoring the Future survey, which included responses from 8th, 10th, and 12th-grade students regarding their perceptions of fentanyl use risks.

Key Findings

  • Fentanyl is involved in a significant proportion of adolescent overdose deaths.
  • The study provides the first national estimates of perceived risk of fentanyl use among adolescents.
  • Demographic factors such as sex, race, and parental education level were analyzed to assess variations in risk perception.
  • Survey response rates were 86% for 8th graders, 81% for 10th graders, and 77% for 12th graders.
  • Perceived risk was assessed across three levels of use: experimental, occasional, and regular.

Clinical Implications

The findings indicate a potential gap in adolescents' awareness of the risks associated with fentanyl use, suggesting that enhanced public awareness campaigns may be necessary. Targeted prevention strategies could be developed based on demographic insights from the study.

Conclusion

This research underscores the importance of understanding adolescents' perceptions of fentanyl risks to inform public health strategies aimed at reducing overdose deaths.

Related Resources & Content

  1. JAMA Network Open, 2023 -- Hospital-Based Management of Opioid Use Disorder in the Fentanyl Era—The Role and Limits of Expert Consensus
  2. Stat News, 2026 -- Super-potent synthetic opioids called nitazenes are spreading across the U.S.
  3. Drug Safety, 2014 -- Assessing Drug-Seeking Behaviors: Evaluating the Applicability in Observational Cohort Studies for Post-Marketing Risk Management
  4. Most Common Drugs in U.S. Overdose Deaths: 2017–2023 | Blogs | CDC, 2026
  5. BMC Psychiatry (Springer) — Prescription drug misuse and risk factors among Somali adolescents: a qualitative study exploring peer influence, stress, and academic pressure
  6. Most Common Drugs in U.S. Overdose Deaths: 2017–2023 | Blogs | CDC
  7. Clinical Practice Guideline: Assessment and Treatment of Adolescents and Young Adults With Substance Use Disorders and Problematic Substance Use (Excluding Tobacco) - ScienceDirect
  8. Effectiveness of naloxone distribution in community settings to reduce opioid overdose deaths among people who use drugs: a systematic review and meta-analysis | BMC Public Health | Springer Nature Link

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