Glofitamab in the sequential treatment of relapsed/refractory B-Cell lymphoma: a single-center real-world study - Report - MDSpire

Glofitamab in the sequential treatment of relapsed/refractory B-Cell lymphoma: a single-center real-world study

  • By

  • Haoran Xu

  • Fangce Wang

  • Chenbo Sun

  • Bing Xiu

  • Yi Ding

  • Bin Xue

  • Aibin Liang

  • Wenjun Zhang

  • July 7, 2026

  • 0 min

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Clinical Report: Efficacy of Glofitamab in Sequential Treatment Approaches

Overview

This study evaluates the efficacy of Glofitamab in patients with relapsed/refractory B-cell lymphoma through various sequential treatment strategies.

Background

Relapsed or refractory B-cell lymphoma presents significant treatment challenges, with a considerable proportion of patients not achieving long-term remission. Glofitamab, a bispecific antibody, offers a novel therapeutic option, particularly in cases where traditional therapies have failed.

Data Highlights

No numerical data available in the provided source material.

Key Findings

  • Glofitamab demonstrated controllable safety and durable anti-tumor activity in three clinical scenarios.
  • Patients receiving Glofitamab after CAR-T therapy failure experienced clinical benefits.
  • The study included 24 patients with various types of relapsed/refractory B-cell lymphoma.
  • Sequential treatment strategies involving Glofitamab were explored, including as a rescue therapy and bridging therapy.

Clinical Implications

Clinicians should consider Glofitamab in sequential treatment strategies for patients with relapsed/refractory B-cell lymphoma.

Conclusion

Further studies are warranted to establish optimal treatment sequences for Glofitamab.

Related Resources & Content

  1. The ASCO Post, 2021 -- Glofitamab for Relapsed or Refractory B-Cell Lymphoma KEY POINTS
  2. Blood Cancer Journal, 2025 -- Combination of Glofitamab and Tislelizumab in Patients with Relapsed/Refractory Diffuse Large B-Cell Lymphoma: A Pilot Study at a Single Institution
  3. The ASCO Post, 2025 -- Glofitamab Plus Polatuzumab Vedotin in Relapsed or Refractory Large B-Cell Lymphoma
  4. Blood Cancer Journal, 2025 -- Comparative Analysis of CAR-T Therapy and Bispecific Antibodies as Subsequent Treatments for Relapsed Follicular Lymphoma: A Systematic Review and Meta-Analysis
  5. FDA Label, 2025 -- Glofitamab
  6. Glofitamab with gemcitabine and oxaliplatin for treating relapsed or refractory diffuse large B-cell lymphoma
  7. May 20-21, 2025 Meeting of the Oncologic Drugs Advisory Committee
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  9. Glofitamab with gemcitabine and oxaliplatin for treating relapsed or refractory diffuse large B-cell lymphoma - NCBI Bookshelf
  10. Infectious Complications in Patients with B-Cell Non-Hodgkin Lymphoma Treated with Bispecific Antibodies - PMC
  11. SEOM–GOTEL clinical guidelines on diffuse large B-cell lymphoma (update 2025) - PMC
  12. Glofitamab in refractory or relapsed diffuse large B cell lymphoma after failing CAR-T cell therapy: a phase 2 LYSA study | Nature Cancer
  13. Short ramp-up glofitamab halves mortality risk after anti-CD19 CAR T-cell therapy failure in patients with diffuse large B-cell lymphoma: final results of the LYSA BiCAR phase 2 trial with a pre-specified external control arm - PubMed
  14. Real-world outcomes of patients with aggressive B-cell lymphoma treated with epcoritamab or glofitamab - ScienceDirect
  15. A prospective study of prophylactic dexamethasone with glofitamab in relapsed/refractory large B-cell lymphoma - PMC

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