Case Report: Complete endoscopic submucosal dissection for occult superficial esophageal squamous cell carcinoma concealed by a large esophageal leiomyoma - Report - MDSpire

Case Report: Complete endoscopic submucosal dissection for occult superficial esophageal squamous cell carcinoma concealed by a large esophageal leiomyoma

  • By

  • Xiaoying Yang

  • Yaowen Hu

  • Wangyang Chen

  • Shengyu Zhang

  • Yonglin Wang

  • Kun He

  • Qingwei Jiang

  • Dong Wu

  • May 20, 2026

  • 0 min

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Endoscopic Submucosal Dissection for Hidden Superficial ESCC Case Study

Overview

This report details a case of superficial esophageal squamous cell carcinoma (ESCC) masked by a large esophageal leiomyoma. Endoscopic submucosal dissection (ESD) was successfully performed, leading to complete resection and favorable outcomes without complications.

Background

The coexistence of esophageal squamous cell carcinoma and leiomyoma is rare, posing significant diagnostic challenges. Benign-appearing lesions can obscure malignant changes, necessitating careful evaluation to avoid missed diagnoses. This case emphasizes the importance of advanced endoscopic techniques in identifying occult malignancies.

Data Highlights

No numerical data or trial data available in the article.

Key Findings

  • A 53-year-old woman was diagnosed with superficial ESCC concealed by a leiomyoma.
  • Subtle mucosal irregularity led to further evaluation and confirmation of carcinoma in situ.
  • Selective ESD achieved en bloc resection with negative margins and no complications.
  • Postoperative pathology indicated submucosal invasion, prompting recommendations for additional surgery, which the patient declined.
  • At 2-year follow-up, there was no recurrence of carcinoma, and the leiomyoma remained stable.

Clinical Implications

Expand on the role of multidisciplinary management and provide examples of adjuvant therapies.

Conclusion

Reiterate the significance of the case in the context of existing literature on ESCC and leiomyoma.

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  2. Techniques in Coloproctology, 2025 -- Management Strategies for Giant Colorectal Lesions Exhibiting Muscle Retracting Sign (MRS+): The Role of Gravitational Traction in Endoscopic Submucosal Dissection
  3. Surgical Endoscopy, 2023 -- An Innovative Anatomical Overview of the Esophagus: The Supracarinal Mesoesophagus
  4. Surgical Endoscopy, 2025 -- Outcomes of Early Stage Large Esophageal Carcinoma Patients Following Double- and Single-Tunnel Super Minimally Invasive Surgery: A Multicenter Retrospective Analysis
  5. Endoscopic submucosal dissection for superficial gastrointestinal lesions: European Society of Gastrointestinal Endoscopy (ESGE) Guideline - Update 2022
  6. Endoscopic submucosal dissection versus endoscopic mucosal resection for early esophageal neoplasia: A systematic review and meta-analysis - ScienceDirect
  7. Guideline-based selection for endoscopic resection
  8. Endoscopic submucosal dissection versus endoscopic mucosal resection for early esophageal neoplasia: A systematic review and meta-analysis - ScienceDirect
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