Temporal trends and projected mortality of myocardial infarction and heart failure in the United States, 1999–2035: a CDC WONDER analysis - Report - MDSpire

Temporal trends and projected mortality of myocardial infarction and heart failure in the United States, 1999–2035: a CDC WONDER analysis

  • By

  • Muhammad Hussain Azam

  • Muhammad Hassan Azam

  • Divesh Sunil Sachdev

  • Hasibullah Aminpoor

  • Taha Ahmed

  • Talha Aamir

  • Muhammad Tayyab Azam

  • Nazila Dalir

  • Faizan Ahmed

  • July 9, 2026

  • 0 min

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Trends in Mortality Rates and Future Projections for Myocardial Infarction and Heart Failure

Overview

This study analyzes mortality trends related to myocardial infarction (MI) and heart failure (HF) in the U.S. from 1999 to 2024, projecting future rates through 2035. Significant demographic and geographic disparities persist, with higher mortality rates observed in men, non-Hispanic Black individuals, and rural populations.

Background

Myocardial infarction and heart failure are leading causes of cardiovascular mortality in the United States. Understanding mortality trends and projections is crucial for public health.

Data Highlights

YearAAMR (per 100,000)
199915.32
20247.55
2035 (projected)8.41

Key Findings

  • From 1999 to 2024, there were 552,835 MI- and HF-related deaths in the U.S.
  • The mean age-adjusted mortality rate (AAMR) declined from 15.32 in 1999 to 7.55 in 2024.
  • Mortality rates were higher in men (12.33) compared to women (7.87) per 100,000 population.
  • Non-Hispanic Black individuals had higher mortality rates (10.59) compared to non-Hispanic White (9.92) and Hispanic individuals (7.70).
  • The South had the highest regional mortality burden (10.52), while the Northeast had the lowest (8.34).
  • Adults aged ≥65 years had the highest mortality rates, with increasing rates observed in those aged 25–44 years after 2010.

Clinical Implications

The findings highlight the importance of monitoring MI and HF mortality trends among high-risk populations.

Conclusion

While there has been a significant decline in MI- and HF-related mortality from 1999 to 2024, disparities remain evident across demographics and regions.

Related Resources & Content

  1. CDC WONDER, 2024 -- Trends in Mortality Rates and Future Projections for Myocardial Infarction and Heart Failure
  2. Frontiers in Cardiovascular Medicine — Temporal trends and disparities in heat-related cardiovascular mortality in the United States (1999–2024): a CDC WONDER analysis
  3. Frontiers in Cardiovascular Medicine — Mortality trends and disparities in older U.S. adults with atrial fibrillation and COPD: a 1999–2020 CDC WONDER analysis with forecast to 2030
  4. Frontiers in Cardiovascular Medicine — Opioid overdose and cardiovascular disease-related mortality: a retrospective analysis using real-world data from the USA, 1999–2023
  5. Frontiers in Endocrinology — Mortality trends in diabetes with proxy-defined steatotic liver disease in the United States, 1999–2023
  6. 2025 ACC/AHA/ACEP/NAEMSP/SCAI Guideline for the Management of Patients With Acute Coronary Syndromes: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines | JACC
  7. AHA/ACC/ESC/WHF Expert Consensus Document: Second Universal Definition of Heart Failure (2026) | JACC
  8. 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines | JACC
  9. Early Discontinuation of Aspirin after PCI in Low-Risk Acute Myocardial Infarction | New England Journal of Medicine
  10. Beta-Blockers after Myocardial Infarction without Reduced Ejection Fraction | New England Journal of Medicine
  11. 10. Cardiovascular Disease and Risk Management: Standards of Care in Diabetes—2025
  12. Vital Statistics Rapid Release, Number 44 (July 2026)
  13. Products - Data Briefs - Number 548 - January 2026
  14. Provisional Mortality by Multiple Cause of Death

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