Progression of Coronary Calcium Detected on Routine Chest CT Enhances Cardiovascular Risk Assessment in Individuals with Inflammatory Bowel Disease: Findings from a Multicenter Study - Report - MDSpire
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Progression of Coronary Calcium Detected on Routine Chest CT Enhances Cardiovascular Risk Assessment in Individuals with Inflammatory Bowel Disease: Findings from a Multicenter Study
Progression of Coronary Calcium Enhances Cardiovascular Risk Assessment in IBD
Overview
Enhance clarity on the significance of CAC assessment in IBD patients compared to traditional risk factors.
Background
Patients with inflammatory bowel disease (IBD) are at an increased risk for atherosclerotic cardiovascular disease (ASCVD), which is often underestimated by traditional risk factors. Chronic inflammation associated with IBD contributes to this elevated risk, necessitating improved risk assessment tools. The study explores the prognostic value of CAC progression in IBD patients, aiming to refine cardiovascular risk stratification.
Data Highlights
Measure
Value
MACE Incidence
59 patients
AF Incidence
41 patients
CAC Progression Rate
27.6%
HR for MACE (CAC Progression)
7.41 (P < 0.001)
C-index Improvement
0.67 to 0.73
NRI Improvement
0.22 (P < 0.001)
Key Findings
CAC progression occurred in 27.6% of IBD patients and predicted MACE with a hazard ratio of 7.41 (P < 0.001).
Graded risk was observed with relative HR of 10.31, absolute HR of 8.14, and incident HR of 5.22 (all P < 0.001).
Adding CAC progression to conventional risk factors improved the C-index from 0.67 to 0.73.
Baseline CAC provided only modest predictive value (C-index 0.67 to 0.68; NRI 0.04, P = 0.021).
CAC progression was also associated with an increased risk of incident atrial fibrillation.
Clinical Implications
The findings underscore the importance of incorporating CAC progression into cardiovascular risk assessments for patients with IBD. Clinicians should consider routine chest CT scans as a valuable tool for identifying patients at higher risk for cardiovascular events, potentially guiding preventive strategies.
Conclusion
Reiterate the potential impact of revised risk stratification on patient outcomes.
