Clinical Report: Pediatric Nasopharyngeal Carcinoma Presenting as Benign Lymphadenopathy
Overview
This report details two pediatric cases of nasopharyngeal carcinoma (NPC) initially misdiagnosed as benign lymphoproliferative disorders.
Background
Pediatric nasopharyngeal carcinoma (NPC) is a rare malignancy that often presents with cervical lymphadenopathy.
Data Highlights
No numerical data or trial data presented in the article.
Key Findings
['Two pediatric cases of NPC presented with isolated cervical lymphadenopathy.', 'Initial misdiagnoses included Kimura disease and classical Hodgkin lymphoma.', 'Both patients underwent multimodal chemoradiotherapy and are under follow-up.', 'Persistent cervical lymphadenopathy in children should prompt early biopsy and cytokeratin staining.', 'EBER in-situ hybridization is recommended to expedite diagnosis.']
Clinical Implications
Maintain a high index of suspicion for NPC in pediatric patients with persistent cervical lymphadenopathy.
Conclusion
The cases presented illustrate the diagnostic challenges of pediatric NPC and the importance of recognizing its potential to mimic benign conditions. Enhanced awareness and diagnostic protocols are necessary to improve outcomes in affected children.
